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Neuroradiology |
1 From Harvard Medical School (W.A.C., L.H.S., R.G.G., P.W.S., W.J.K., A.G.S.); Division of Neuroradiology (R.G.G., P.W.S., A.G.S.), NMR Center (W.A.C., R.G.G., O.W., C.B.H., P.W.S., A.G.S.), Department of Neurology (L.H.S., W.J.K.), Massachusetts General Hospital, 13th St, Bldg 149, mail code 2301, Boston, MA 02129. Received Aug 15, 2000; revision requested Sep 26; final revision received Mar 14, 2001; accepted Apr 6. Supported by Public Health Service grant R01NS8477-01 and grant 5P41-RR14075. W.A.C. supported in part by American Heart Association Student Scholarship in Cerebrovascular Disease and educational stipend from Harvard Medical School Office of Enrichment Programs. Address correspondence to A.G.S. (e-mail: sorensen@nmr.mgh.harvard.edu).
PURPOSE: To determine whether the evolution of the core apparent diffusion coefficient (ADC) of water in ischemic stroke varies with patient age or infarct etiology.
MATERIALS AND METHODS: One hundred forty-seven patients with stroke underwent 236 diffusion-weighted magnetic resonance imaging examinations. Etiologies of lesions were classified according to predefined criteria; in 224 images, the diagnosis of lacune could be firmly established or excluded. ADC was measured in the center of each lesion and in contralateral normal-appearing brain. A model was used to describe the time course of relative ADC (rADC), which is calculated by dividing the lesion ADC by the contralateral ADC, and to test for age- or etiology-related differences in this time course.
RESULTS: Transition from decreasing to increasing rADC was estimated at 18.5 hours after stroke onset. In subgroup analysis, transition was earlier in nonlacunes than in lacunes (P = .02). There was a trend toward earlier transition in patients older than the median age of 66.0 years, compared with younger patients (P = .06). Pseudonormalization was estimated at 216 hours. Among nonlacunes, the rate of subsequent rADC increase was more rapid in younger patients than in older patients (P = .001). Within the smaller sample of lacunes, however, no significant age-related difference in this rate was found.
CONCLUSION: Differences in ADC depending on the patient’s age and infarct etiology suggest differing rates of ADC progression.
Index terms: Aging • Brain, diffusion, 13.12144 • Brain, infarction, 13.4352 • Brain, MR, 13.121411 • Magnetic resonance (MR), diffusion study, 13.12144
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