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Normal Values for Sincalide Cholescintigraphy: Comparison of Two Methods¹

¹ From the Division of Nuclear Medicine, Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (H.A.Z., A.K.A., A.A.M.Z.); and Larry R. Muenz and Associates, Gaithersburg, Md (L.R.M.). Received December 14, 2000; revision requested January 26, 2001; revision received April 25; accepted May 21. Address correspondence to H.A.Z. (e-mail: ziessmah@gunet.georgetown.edu).

PURPOSE: To establish normal gallbladder ejection fraction (GBEF) values for two sincalide (cholecystokinin [CCK]) infusion dose rates, 0.01 µg per kilogram of body weight infused for 3 minutes and 0.01 µg/kg infused for 60 minutes.

MATERIALS AND METHODS: Twenty healthy subjects were examined. GBEFs were calculated for the 3-minute infusion and for each 15-minute interval for the 60-minute infusion. Normal values were determined by using the mean ± 2 SDs and a more rigorous statistical analysis.

RESULTS: With the 3-minute infusion, GBEFs were significantly more variable than with the 45- and 60-minute values for the 60-minute infusion (P < .01, .002). With intervals including 95% of the population, the GBEF lower normal range was 16.8% for the 3-minute infusion but 31% and 41% for the 45- and 60-minute values, respectively. GBEFs of less than 35% were noted in six (30%) of 20 healthy subjects with the 3-minute infusion but in only one with the 60-minute infusion. Hepatobiliary ultrasonography was performed in six of seven subjects with GBEF of 36% or less, and US findings in all six were normal.

CONCLUSION: A 3-minute infusion of sincalide, 0.01 µg/kg, produces too variable a GBEF response to establish a clinically useful normal range. With 0.01 µg/kg infused for 60 minutes, clinically useful normal values were established at 45 and 60 minutes.

Index terms: Cholecystitis, 762.285 • Gallbladder, function • Gallbladder, radionuclide studies, 762.1216 • Hormones

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