HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2213010533v1 221/3/676    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lund, G. K. Articles by Saeed, M. Search for Related Content PubMed PubMed Citation Articles by Lund, G. K. Articles by Saeed, M.

Assessment of Nicorandil Therapy in Ischemic Myocardial Injury by Using Contrast-enhanced and Functional MR Imaging¹

¹ From the Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Rm L-308, San Francisco, CA 94143-0628 (G.K.L., C.B.H., M.F.W., N.W., M.S.); and Schering AG, Berlin, Germany (H.J.W.). Received February 28, 2001; revision requested April 2; revision received June 7; accepted July 5. Supported in part by a gift from Schering AG, Berlin, Germany. G.K.L. supported in part by a scholarship from the University Hospital Eppendorf, Hamburg, Germany. N.W. supported in part by a scholarship from the Max-Kade Foundation, New York, NY. Address correspondence to M.S. (e-mail: maythem.saeed@radiology.ucsf.edu).

PURPOSE: To determine the potential of mesoporphyrin– and gadopentetate dimeglumine–enhanced and functional magnetic resonance (MR) imaging in the assessment of the acute effect of nicorandil on ischemic injury of the myocardium.

MATERIALS AND METHODS: Spin-echo MR imaging was used to monitor changes in myocardial contrast and function in reperfused myocardial injury. Inversion-recovery echo-planar MR imaging was used to depict the injured region. Myocardial injury in rats was produced by using 30 minutes of coronary occlusion followed by 24 hours reperfusion. Nicorandil (n = 9) was infused during occlusion and early reperfusion. Control animals (n = 11) received no therapy. At 24 hours, after administration of mesoporphyrin and gadopentetate dimeglumine and histochemical staining, the function and size of the injured region of the left ventricle (LV) were determined. A t test was used to compare data between groups of animals, whereas regression and Bland-Altman analyses were used to determine correlation and agreement between MR imaging and histomorphometry, respectively.

RESULTS: Treated animals showed reduced infarction size as compared with the control group from 25.6% ± 7.9 (SD) to 7.9% ± 6.8 of LV myocardial area (P < .001), as defined with mesoporphyrin-enhanced MR imaging; while the size of the rim increased from 10.8% ± 10.0 to 16.1% ± 14.4 (P < .05). The diastolic-midventricular cavity area was smaller in treated animals (15.2 mm² ± 4.3) compared with the control group (28.5 mm² ± 7.9; P < .001). At functional MR imaging, nicorandil improved systolic reduction in LV cavity area (57.5% ± 17.3) compared with the control group (38.0% ± 16.0; P < .05) and preserved regional LV wall thickening at the site of injury (12.2% ± 11.1 in treated group vs 0.3% ± 8.6 in the control group; P < .05).

CONCLUSION: Contrast material–enhanced MR imaging has the potential to demonstrate reduction in size of ischemically injured myocardium, whereas functional MR imaging demonstrated the recovery of LV function 24 hours after nicorandil therapy.

Index terms: Heart, experimental studies, 511.12143 • Heart, MR, 511.121413, 511.121416, 511.12143 • Myocardium, infarction, 511.771 • Myocardium, ischemia, 511.1939 • Myocardium, MR, 511.121413, 511.121416, 511.12143

This article has been cited by other articles:

				G. A. Krombach, C. B. Higgins, M. Chujo, and M. Saeed Gadomer-enhanced MR Imaging in the Detection of Microvascular Obstruction: Alleviation with Nicorandil Therapy Radiology, August 1, 2005; 236(2): 510 - 518. [Abstract] [Full Text] [PDF]

				S. Schalla, C. B. Higgins, M. Chujo, and M. Saeed Effect of Potassium-Channel Opener Therapy on Reperfused Infarction in Hypertrophied Hearts: Demonstration of Preconditioning by Using Functional and Contrast-Enhanced Magnetic Resonance Imaging Journal of Cardiovascular Pharmacology and Therapeutics, July 1, 2004; 9(3): 193 - 202. [Abstract] [PDF]

				Y. Ni, S. Dymarkowski, F. Chen, J. Bogaert, G. Marchal, T.-H. Lim, and S. S. Lee Proper Handling of Research with Invalid Conclusions [letter] * Drs Lim and Lee respond: Radiology, November 1, 2003; 229(2): 608 - 610. [Full Text] [PDF]

				G. A. Krombach, M. F. Wendland, C. B. Higgins, and M. Saeed MR Imaging of Spatial Extent of Microvascular Injury in Reperfused Ischemically Injured Rat Myocardium: Value of Blood Pool Ultrasmall Superparamagnetic Particles of Iron Oxide Radiology, November 1, 2002; 225(2): 479 - 486. [Abstract] [Full Text] [PDF]

				Y. Ni, S. Dymarkowski, F. Chen, J. Bogaert, G. Marchal, S. H. Choi, S. S. Lee, S. I. Choi, S. T. Kim, K. H. Lim, et al. Occlusive Myocardial Infarction Enhanced or Not Enhanced with Necrosis-avid Contrast Agents at MR Imaging * Dr Choi and colleagues respond: Radiology, November 1, 2002; 225(2): 603 - 606. [Full Text] [PDF]

				M. Saeed, N. Watzinger, G. A. Krombach, G. K. Lund, M. F. Wendland, M. Chujo, and C. B. Higgins Left Ventricular Remodeling after Infarction: Sequential MR Imaging with Oral Nicorandil Therapy in Rat Model Radiology, September 1, 2002; 224(3): 830 - 837. [Abstract] [Full Text] [PDF]