HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2213010106v1 221/3/740    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cho, S. G. Articles by Suh, C. H. Search for Related Content PubMed PubMed Citation Articles by Cho, S. G. Articles by Suh, C. H.

Chronic Hepatitis: In Vivo Proton MR Spectroscopic Evaluation of the Liver and Correlation with Histopathologic Findings¹

¹ From the Departments of Radiology (S.G.C., M.Y.K., H.J.K., C.H.S.), Internal Medicine (Y.S.K., W.C.), Surgery (S.H.S., K.C.H.), and Pathology (Y.B.K.), Inha University College of Medicine, 7-206 3rd St, Shinheung-Dong, Choong-Gu, Inchon 400-711, Korea; and Nuclear Magnetic Resonance Laboratory, Asan Institute for Life Sciences, Seoul, Korea (J.H.L.). From the 1999 RSNA scientific assembly. Received December 4, 2000; revision requested January 24, 2001; revision received April 16; accepted May 14. Supported by Inha University research grant INHA-21074. Address correspondence to S.G.C. (e-mail: soongucho@netsgo.com).

PURPOSE: To correlate the in vivo hydrogen 1 (¹H) magnetic resonance (MR) spectroscopic features of the chronic hepatitis–involved liver with the histopathologic stages of fibrosis.

MATERIALS AND METHODS: Seventy-five patients with chronic hepatitis were examined with ¹H MR spectroscopy, which was performed in the right hepatic lobe. The peak areas of glutamine and glutamate complex (Glx), phosphomonoesters (PME), glycogen and glucose complex (Glyu), and lipid were measured on the liver spectra. The histopathologic features were correlated with the in vivo ¹H MR spectroscopic findings at each stage of chronic hepatitis. Fifteen healthy volunteers also were included as a control group.

RESULTS: ¹H MR spectroscopy depicted Glx, PME, Glyu, and lipid in all livers. In the normal livers, the calculated mean (± SD) relative metabolite-to-lipid ratios of Glx, PME, and Glyu were 0.14 ± 0.04, 0.03 ± 0.01, and 0.21 ± 0.04, respectively. The mean value of each metabolite-to-lipid ratio was significantly different between all stages of chronic hepatitis, and with the exception of the mean ratio at the interval between stages 0 and 1 (P > .05), the mean value increased significantly with increasing stage (P < .05). A pronounced peak was demonstrated at 3.9–4.1 ppm at ¹H MR spectroscopy of all stages of chronic hepatitis except stage 0.

CONCLUSION: The increased Glx, PME, and Glyu levels relative to the lipid content with chronic hepatitis indicated the severity of fibrosis and thus were concordant with the histopathologic stages. In vivo ¹H MR spectroscopy might be a substitute for liver biopsy in the diagnosis and staging of chronic hepatitis.

Index terms: Hepatitis, 761.291 • Liver, cirrhosis, 761.794 • Liver, diseases, 761.291, 761.794 • Magnetic resonance (MR), spectroscopy, 761.12145

This article has been cited by other articles:

				A. Orlacchio, F. Bolacchi, M. Cadioli, A. Bergamini, V. Cozzolino, M. Angelico, and G. Simonetti Evaluation of the Severity of Chronic Hepatitis C with 3-T1H-MR Spectroscopy Am. J. Roentgenol., May 1, 2008; 190(5): 1331 - 1339. [Abstract] [Full Text] [PDF]

				C. G. Lall, A. M. Aisen, N. Bansal, and K. Sandrasegaran Nonalcoholic Fatty Liver Disease Am. J. Roentgenol., April 1, 2008; 190(4): 993 - 1002. [Abstract] [Full Text] [PDF]

				C.-Y. Chen, C.-W. Li, Y.-T. Kuo, T.-S. Jaw, D.-K. Wu, J.-C. Jao, J.-S. Hsu, and G.-C. Liu Early Response of Hepatocellular Carcinoma to Transcatheter Arterial Chemoembolization: Choline Levels and MR Diffusion Constants--Initial Experience Radiology, May 1, 2006; 239(2): 448 - 456. [Abstract] [Full Text] [PDF]

				A. Qayyum, J. S. Goh, S. Kakar, B. M. Yeh, R. B. Merriman, and F. V. Coakley Accuracy of Liver Fat Quantification at MR Imaging: Comparison of Out-of-Phase Gradient-Echo and Fat-saturated Fast Spin-Echo Techniques--Initial Experience Radiology, November 1, 2005; 237(2): 507 - 511. [Abstract] [Full Text] [PDF]

				A. K. P. Lim, G. Hamilton, N. Patel, J. D. Bell, and S. D. Taylor-Robinson 1H MR Spectroscopy in the Evaluation of the Severity of Chronic Liver Disease Radiology, January 1, 2003; 226(1): 288 - 289. [Full Text] [PDF]