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Published online before print October 30, 2001, 10.1148/radiol.2213010444
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(Radiology. 2001;221:795-801.)
© RSNA, 2001

Neuroradiology

Treatment of Acute Basilar Artery Thrombosis with a Combination of Systemic Alteplase and Tirofiban, a Nonpeptide Platelet Glycoprotein IIb/IIIa Inhibitor: Report of Four Cases1

Ulrich Junghans, MD, Rüdiger J. Seitz, MD, Hans J. Wittsack, PhD, Albrecht Aulich, MD and Mario Siebler, MD

1 From the Department of Neurology (U.J., R.J.S., M.S.) and Institute of Diagnostic Radiology (H.J.W., A.A.), University Hospital Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany. Received February 12, 2001; revision requested March 28; revision received May 14; accepted June 5. Supported by the Deutsche Forschungsgemeinschaft (SFB 194, A13) and BMBF (Kompetenznetzwerk Schlaganfall, B5). Address correspondence to M.S. (e-mail: siebler@uni-duesseldorf.de).

In four patients with acute basilar artery thrombosis, complete arterial recanalization and good neurologic outcome were achieved with a treatment combining alteplase with tirofiban. In no cases were cerebral or extracerebral hemorrhagic complications observed. Combined fibrinolytic agents and glycoprotein IIb/IIIa inhibitors may have high potential in the treatment of acute cerebrovascular thrombosis.

Index terms: Arteries, basilar, 1753.751 • Arteries, stenosis or obstruction, 1753.721, 1753.751 • Thrombolysis




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