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Nuclear Medicine |
1 From the Division of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. Received January 9, 2001; revision requested March 5; revision received April 20; accepted May 21. Supported by a special research grant from Ghent University and the Flemish government (BOZF 01104699). Address correspondence to K.J.V.L. (e-mail: koen.vanlaere@rug.ac.be).
PURPOSE: To investigate brain perfusion at single photon emission computed tomography (SPECT) as a function of age and sex in healthy adult volunteers and to correlate perfusion with gray matter concentration determined by using voxel-based morphometry (VBM).
MATERIALS AND METHODS: Eighty-one healthy volunteers underwent both technetium 99m ethylene cysteine dimer SPECT and three-dimensional magnetization preparation rapid acquisition gradient-echo magnetic resonance (MR) imaging. Statistical parametric mapping was used to conduct VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of the perfusion data and more specifically in brain areas showing significant perfusion changes.
RESULTS: VBM data, as compared with perfusion changes, indicated a more symmetric age-related gray matter volume decrease along the Sylvian fissure and in subcortical regions (P < .001). The combination of functional and structural changes indicated a relatively lower functional decrease with aging, as compared with the structural atrophy in the visual, parietal, sensorimotor, and right prefrontal cortices. Significant relative morphologic sex-based differences were found in the cerebellar and temporal cortices, but the comparison did not reveal significant differences between the functional and morphometric data.
CONCLUSION: Age-related perfusion changes are paralleled by similar more symmetric changes in gray matter concentration, which are more prominent than the perfusion changes in some regions. No sex-based differences between perfusion and gray matter concentration were found.
Index terms: Brain, atrophy, 10.83 • Brain, MR, 13.12141, 13.121412 • Brain, perfusion • Brain, radionuclide studies, 13.12162, 13.12163 • Brain, SPECT, 13.12162
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