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Published online before print November 5, 2001, 10.1148/radiol.2221010560
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(Radiology 2002;222:127-135.)
© RSNA, 2001

Cardiac Imaging

MR Flow Mapping in Coronary Artery Bypass Grafts: A Validation Study with Doppler Flow Measurements1

Susan E. Langerak, MSc, Patrik Kunz, PhD, Hubert W. Vliegen, MD, J. Wouter Jukema, MD, Aeilko H. Zwinderman, PhD, Paul Steendijk, PhD, Hildo J. Lamb, PhD, Ernst E. van der Wall, MD and Albert de Roos, MD

1 From the Depts of Cardiology (S.E.L., H.W.V., J.W.J., P.S., E.E.v.d.W.), Radiology (S.E.L., P.K., H.J.L., A.d.R.), and Medical Statistics (A.H.Z.), Leiden Univ Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands; and the Interuniversity Cardiology Inst of the Netherlands, Utrecht (S.E.L, E.E.v.d.W., A.d.R.). Received Mar 2, 2001; revision requested Apr 11; revision received Jun 8; accepted Jul 5. S.E.L. supported by grant 97.173 from the Netherlands Heart Foundation. Address correspondence to A.d.R. (e-mail: a.de_roos@lumc.nl).

PURPOSE: To validate fast magnetic resonance (MR) flow mapping with intravascular Doppler flow measurements in vitro and in patients with nonstenotic and stenotic coronary artery bypass grafts.

MATERIALS AND METHODS: MR and Doppler flow measurements were performed in a small-diameter flow phantom with physiologic flow conditions and at baseline and during adenosine stress in 27 grafts in 23 patients, who were scheduled for cardiac catheterization. At invasive analysis, the grafts were divided into those with stenosis of less than 50% (nonstenotic) and those with stenosis greater than or equal to 50% (stenotic). In vitro velocity values and velocity values in nonstenotic and stenotic grafts were compared with linear regression analysis, and the in vitro interstudy variability was determined.

RESULTS: Excellent correlations in average peak velocity (r = 0.99, P < .001) and diastolic peak velocity (r = 0.99, P < .001) were demonstrated in vitro between MR and Doppler flow measurements, with less than 5% interstudy variability. MR and Doppler flow measurements revealed good correlations in peak velocity and velocity reserve both in nonstenotic (n = 20) (average peak velocity: r = 0.81, P < .001; diastolic peak velocity: r = 0.83, P < .001; velocity reserve: r = 0.56, P = .010) and stenotic (n = 7) (average peak velocity: r = 0.83, P < .001; diastolic peak velocity: r = 0.78, P = .001; velocity reserve: r = 0.70, P = .078) grafts.

CONCLUSION: Fast MR flow mapping provides noninvasive measures of peak velocity and velocity reserve, which closely correlate with Doppler values both in vitro and in nonstenotic and stenotic grafts.

Index terms: Arteries, grafts and prostheses, 943.1269, 949.1269 • Arteries, MR, 544.121416, 544.12144, 943.129412, 943.129416, 943.12944 • Arteries, stenosis or obstruction, 943.721, 949.721 • Blood, flow dynamics • Coronary vessels, flow dynamics, 544.731 • Magnetic resonance (MR), vascular studies, 943.12944 • Ultrasound (US), Doppler studies, 943.12985




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