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Published online before print November 12, 2001, 10.1148/radiol.2221001808
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(Radiology 2002;222:179-183.)
© RSNA, 2001

Musculoskeletal Imaging

Radiation-induced Changes in MR Signal Intensity and Contrast Enhancement of Lumbosacral Vertebrae: Do Changes Occur Only Inside the Radiation Therapy Field?1

Shoichiro Otake, MD, PhD, Nina A. Mayr, MD2, Toshihiro Ueda, MD, PhD, Vincent A. Magnotta, PhD and William T. C. Yuh, MD, MSEE2

1 From the Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City. Received November 15, 2000; revision requested January 10, 2001; final revision received June 4; accepted August 1. Supported in part by National Institutes of Health grant 1 RO1 CA71906-01A2. Address correspondence to S.O., Department of Radiology, Toki Municipal General Hospital, 703-24 Tokitsuguchi, Tokitsu-cho, Toki, Gifu 509-5193 Japan.

PURPOSE: To evaluate temporal changes in signal intensity (SI) and degree of contrast enhancement (CE) of bone marrow in lumbosacral vertebrae inside and outside the radiation therapy (RT) field.

MATERIALS AND METHODS: Twenty-three patients with advanced uterine cervical cancer who were treated with RT were prospectively evaluated. Each patient underwent four dynamic magnetic resonance (MR) studies: before RT, 2 and 4 weeks after initiation of RT, and 4 weeks after completion of RT. SI and CE were calculated in all four studies of each patient.

RESULTS: Bone marrow inside the RT field showed steady and marked increase in precontrast SI and early and transient increase in CE at 2 weeks after initiation of RT followed by progressive and marked decrease in CE at 4 weeks after initiation of RT and 4 weeks after completion of RT. Bone marrow outside the RT field showed slight increase in precontrast SI and steady and moderate decrease in CE to a lesser degree without early increase as seen in bone marrow inside the RT field.

CONCLUSION: RT causes an increase in precontrast SI predominantly in bone marrow inside the RT field. However, a decrease in CE is seen in bone marrow not only inside but also outside the RT field.

Index terms: Bone marrow, effects of irradiation on, 331.47 • Magnetic resonance (MR), contrast enhancement, 331.121411, 331.12143 • Radiation, injurious effects, 331.47 • Spine, MR, 331.121411, 331.12143




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