| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Nuclear Medicine |
1 From the Divisions of Nuclear Medicine (S.H., E.N., I.B., E.M.) and Diagnostic Radiology (C.A., N.G.), Department of Radiology; and Divisions of Nephrology and Hypertension (T.M., H.P.H.N.) and Endocrinology (M.R.), Department of Internal Medicine, Albert-Ludwigs University, Hugstetter Strasse 55, 79106 Freiburg, Germany. Received March 16, 2001; revision requested April 18; revision received July 17; accepted August 9. Address correspondence to S.H. (e-mail: hoegerle@ukl.uni-freiburg.de).
PURPOSE: To evaluate fluorine 18 (18F) dihydroxyphenylalanine (DOPA) whole-body positron emission tomography (PET) as a biochemical imaging approach for detection of pheochromocytomas.
MATERIALS AND METHODS: 18F DOPA PET and magnetic resonance (MR) imaging were performed in 14 consecutive patients suspected of having pheochromocytomas (five sporadic, nine with von Hippel-Lindau disease); metaiodobenzylguanidine (MIBG) scintigraphy was performed in 12 of these patients. The individual imaging findings were assessed in consensus by specialists in nuclear medicine and radiologists blinded to the results of the other methods. The findings of the functional imaging methods were compared with those of MR imaging, the reference standard. Histologic verification could be obtained in eight patients with nine tumors.
RESULTS: Seventeen pheochromocytomas (11 solitary, three bifocal; 14 adrenal, three extraadrenal) were detected with MR imaging. 18F DOPA PET and MR imaging had concordant results in all 17 tumors. In contrast, MIBG scintigraphy had false-negative results in four patients with three adrenal tumors smaller than 2 cm and one extraadrenal tumor with a diameter of 3.6 cm. On the basis of these data, sensitivities of 100% for 18F DOPA PET and of 71% for MIBG scintigraphy were calculated. Specificity was 100% for both procedures.
CONCLUSION: 18F DOPA PET is highly sensitive and specific for detection of pheochromocytomas and has potential as the functional imaging method of the future.
Index terms: Adrenal gland, MR, 86.121411, 86.121412, 86.121416 • Adrenal gland, neoplasms, 861.328 • Adrenal gland, PET, 86.12163 • Adrenal gland, SPECT, 86.12161, 86.12162, 86.12172, 86.12175 • Fluorine, radioactive • Pheochromocytoma, 861.328
This article has been cited by other articles:
|
|
 |
|
  I. Ilias, C. C. Chen, J. A. Carrasquillo, M. Whatley, A. Ling, I. Lazurova, K. T. Adams, S. Perera, and K. Pacak Comparison of 6-18F-Fluorodopamine PET with 123I-Metaiodobenzylguanidine and 111In-Pentetreotide Scintigraphy in Localization of Nonmetastatic and Metastatic Pheochromocytoma J. Nucl. Med., October 1, 2008; 49(10): 1613 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Jager, R. Chirakal, C. J. Marriott, A. H. Brouwers, K. P. Koopmans, and K. Y. Gulenchyn 6-L-18F-Fluorodihydroxyphenylalanine PET in Neuroendocrine Tumors: Basic Aspects and Emerging Clinical Applications J. Nucl. Med., April 1, 2008; 49(4): 573 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Zelinka, H. J L M Timmers, A. Kozupa, C. C Chen, J. A Carrasquillo, J. C Reynolds, A. Ling, G. Eisenhofer, I. Lazurova, K. T Adams, et al. Role of positron emission tomography and bone scintigraphy in the evaluation of bone involvement in metastatic pheochromocytoma and paraganglioma: specific implications for succinate dehydrogenase enzyme subunit B gene mutations Endocr. Relat. Cancer, March 1, 2008; 15(1): 311 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. T. Hardy, M. Hernandez-Pampaloni, J. R. Saffer, J. S. Scheuermann, L. M. Ernst, R. Freifelder, H. Zhuang, C. MacMullen, S. Becker, N. S. Adzick, et al. Accuracy of [18F]Fluorodopa Positron Emission Tomography for Diagnosing and Localizing Focal Congenital Hyperinsulinism J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4706 - 4711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I S Mackenzie, M Gurnell, K K Balan, H Simpson, K Chatterjee, and M J Brown The use of 18-fluoro-dihydroxyphenylalanine and 18-fluorodeoxyglucose positron emission tomography scanning in the assessment of metaiodobenzylguanidine-negative phaeochromocytoma Eur. J. Endocrinol., October 1, 2007; 157(4): 533 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nanni, S. Fanti, and D. Rubello 18F-DOPA PET and PET/CT J. Nucl. Med., October 1, 2007; 48(10): 1577 - 1579. [Full Text] [PDF]
|
|
|
|
|
|
H. J.L.M. Timmers, M. Hadi, J. A. Carrasquillo, C. C. Chen, L. Martiniova, M. Whatley, A. Ling, G. Eisenhofer, K. T. Adams, and K. Pacak The Effects of Carbidopa on Uptake of 6-18F-Fluoro-L-DOPA in PET of Pheochromocytoma and Extraadrenal Abdominal Paraganglioma J. Nucl. Med., October 1, 2007; 48(10): 1599 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chrisoulidou, G. Kaltsas, I. Ilias, and A. B Grossman The diagnosis and management of malignant phaeochromocytoma and paraganglioma Endocr. Relat. Cancer, September 1, 2007; 14(3): 569 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ilias, A. Sahdev, R. H Reznek, A. B Grossman, and K. Pacak The optimal imaging of adrenal tumours: a comparison of different methods Endocr. Relat. Cancer, September 1, 2007; 14(3): 587 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kaji, J. A Carrasquillo, W M. Linehan, C. C Chen, G. Eisenhofer, P. A Pinto, E. W Lai, and K. Pacak The role of 6-[18F]fluorodopamine positron emission tomography in the localization of adrenal pheochromocytoma associated with von Hippel-Lindau syndrome Eur. J. Endocrinol., April 1, 2007; 156(4): 483 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kauhanen, M. Seppanen, H. Minn, R. Gullichsen, A. Salonen, K. Alanen, R. Parkkola, O. Solin, J. Bergman, T. Sane, et al. Fluorine-18-L-Dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography as a Tool to Localize an Insulinoma or {beta}-Cell Hyperplasia in Adult Patients J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1237 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Franzius, K. Hermann, M. Weckesser, K. Kopka, K. U. Juergens, J. Vormoor, and O. Schober Whole-Body PET/CT with 11C-Meta-Hydroxyephedrine in Tumors of the Sympathetic Nervous System: Feasibility Study and Comparison with 123I-MIBG SPECT/CT J. Nucl. Med., October 1, 2006; 47(10): 1635 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. de Lonlay, A. Simon-Carre, M.-J. Ribeiro, N. Boddaert, I. Giurgea, K. Laborde, C. Bellanne-Chantelot, V. Verkarre, M. Polak, J. Rahier, et al. Congenital Hyperinsulinism: Pancreatic [18F]Fluoro-L-Dihydroxyphenylalanine (DOPA) Positron Emission Tomography and Immunohistochemistry Study of DOPA Decarboxylase and Insulin Secretion J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 933 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Scarsbrook, R. V. Thakker, J. A. H. Wass, F. V. Gleeson, and R. R. Phillips Multiple Endocrine Neoplasia: Spectrum of Radiologic Appearances and Discussion of a Multitechnique Imaging Approach. RadioGraphics, March 1, 2006; 26(2): 433 - 451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. N. Mann, J. M. Link, P. Pham, C. A. Pickett, D. R. Byrd, P. E. Kinahan, K. A. Krohn, and D. A. Mankoff [11C]Metahydroxyephedrine and [18F]Fluorodeoxyglucose Positron Emission Tomography Improve Clinical Decision Making in Suspected Pheochromocytoma Ann. Surg. Oncol., February 1, 2006; 13(2): 187 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Otonkoski, K. Nanto-Salonen, M. Seppanen, R. Veijola, H. Huopio, K. Hussain, P. Tapanainen, O. Eskola, R. Parkkola, K. Ekstrom, et al. Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [18F]-DOPA Positron Emission Tomography Diabetes, January 1, 2006; 55(1): 13 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Ippolito, J. Xu, S. Jain, K. Moulder, S. Mennerick, J. R. Crowley, R. R. Townsend, and J. I. Gordon An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers PNAS, July 12, 2005; 102(28): 9901 - 9906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Ribeiro, P. De Lonlay, T. Delzescaux, N. Boddaert, F. Jaubert, S. Bourgeois, F. Dolle, C. Nihoul-Fekete, A. Syrota, and F. Brunelle Characterization of Hyperinsulinism in Infancy Assessed with PET and 18F-Fluoro-L-DOPA J. Nucl. Med., April 1, 2005; 46(4): 560 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dannenberg, F. H. van Nederveen, M. Abbou, A. A. Verhofstad, P. Komminoth, R. R. de Krijger, and W. N.M. Dinjens Clinical Characteristics of Pheochromocytoma Patients With Germline Mutations in SDHD J. Clin. Oncol., March 20, 2005; 23(9): 1894 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Eisenhofer, S. R Bornstein, F. M Brouwers, N.-K. V Cheung, P. L Dahia, R. R de Krijger, T. J Giordano, L. A Greene, D. S Goldstein, H. Lehnert, et al. Malignant pheochromocytoma: current status and initiatives for future progress Endocr. Relat. Cancer, September 1, 2004; 11(3): 423 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. H. Neumann, C. Pawlu, M. Peczkowska, B. Bausch, S. R. McWhinney, M. Muresan, M. Buchta, G. Franke, J. Klisch, T. A. Bley, et al. Distinct Clinical Features of Paraganglioma Syndromes Associated With SDHB and SDHD Gene Mutations JAMA, August 25, 2004; 292(8): 943 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Pacak, G. Eisenhofer, and D. S. Goldstein Functional Imaging of Endocrine Tumors: Role of Positron Emission Tomography Endocr. Rev., August 1, 2004; 25(4): 568 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Becherer, M. Szabo, G. Karanikas, P. Wunderbaldinger, P. Angelberger, M. Raderer, A. Kurtaran, R. Dudczak, and K. Kletter Imaging of Advanced Neuroendocrine Tumors with 18F-FDOPA PET J. Nucl. Med., July 1, 2004; 45(7): 1161 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Minn, A. Salonen, J. Friberg, A. Roivainen, T. Viljanen, J. Langsjo, J. Salmi, M. Valimaki, K. Nagren, and P. Nuutila Imaging of Adrenal Incidentalomas with PET Using 11C-Metomidate and 18F-FDG J. Nucl. Med., June 1, 2004; 45(6): 972 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ilias and K. Pacak Current Approaches and Recommended Algorithm for the Diagnostic Localization of Pheochromocytoma J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 479 - 491. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Trampal, H. Engler, C. Juhlin, M. Bergstrom, and B. Langstrom Pheochromocytomas: Detection with 11C Hydroxyephedrine PET Radiology, February 1, 2004; 230(2): 423 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Manger In Search of Pheochromocytomas J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4080 - 4082. [Full Text] [PDF]
|
|
|
|
|
|
I. Ilias, J. Yu, J. A. Carrasquillo, C. C. Chen, G. Eisenhofer, M. Whatley, B. McElroy, and K. Pacak Superiority of 6-[18F]-Fluorodopamine Positron Emission Tomography Versus [131I]-Metaiodobenzylguanidine Scintigraphy in the Localization of Metastatic Pheochromocytoma J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4083 - 4087. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
