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Published online before print January 25, 2002, 10.1148/radiol.2223010531
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(Radiology 2002;222:789-793.)
© RSNA, 2002

Special Report

Morphologic Phenotyping with MR Microscopy: The Visible Mouse1

G. Allan Johnson, PhD, Gary P. Cofer, MS, Sally L. Gewalt, MS and Laurence W. Hedlund, PhD

1 From the Center for In Vivo Microscopy, Duke University Medical Center, Rm 141, D Bryan Neuroscience Bldg, Research Dr, Durham, NC 27710. Received March 5, 2001; revision requested April 14; final revision received September 5; accepted September 6. Supported by the National Institutes of Health National Center for Research Resources (P41 RR05959). Address correspondence to G.A.J. (e-mail: gaj@orion.mc.duke.edu).

A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-µm isotropic resolution; limited volumes of the intact specimen, at 50-µm isotropic resolution; and isolated organs, at 25-µm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype.

Supplemental material: (radiology.rsnajnls.org/cgi/content/full/2223010531/DC1)

© RSNA, 2002

Index terms: Animals • Magnetic resonance (MR), technology • Special Reports




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