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Mild Intermittent Asthma: CT Assessment of Bronchial Cross-sectional Area and Lung Attenuation at Controlled Lung Volume¹

¹ From the Departments of Radiology (C.B.A., P.A.G.), Lung Function Investigation, UPRES 2397 (C.S., M.H.B., M.Z.), and Pneumology (T.S.), and the National Institute of Health and Medical Research (U 494) (P.A.G.), Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75651 Paris 13, France; Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France; and Faculté de Médecine Paris XI, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, France (A.C.). Received April 16, 2001; revision requested May 14; revision received July 31; accepted September 17. Supported by Programme Hôspitalier de Recherche Clinique PCRMG94813. Address correspondence to P.A.G. (e-mail: philippe.grenier @psl.ap-hop-paris.fr).

PURPOSE: To evaluate, with thin-section computed tomography (CT), changes in bronchial cross-sectional area and lung attenuation induced by bronchial stimulation in patients with mild intermittent asthma, at a given lung volume monitored with pneumotachography.

MATERIALS AND METHODS: Twelve patients with mild intermittent asthma who were nonsmokers (National Institutes of Health staging) and six nonsmoking healthy volunteers, age and sex ratio–matched, were examined by using helical thin-collimation CT at the level of basal bronchi at 65% of total lung capacity. Three sets of acquisitions were obtained: at baseline and after inhalation of methacholine and then salbutamol. Cross-sectional areas of bronchi greater than 4 mm² were segmented and calculated from CT images. Lung attenuation was measured in the anterior, lateral, and posterior areas of the right lung parenchyma. Gas trapping was evaluated by using thin-section CT at residual volume in six of the patients with asthma. Statistical analysis included two factors repeated-measurement analysis of variance and Mann-Whitney and Kruskal-Wallis nonparametric tests.

RESULTS: Bronchial cross-sectional areas and lung attenuation did not vary significantly compared with baseline values following bronchial challenge in healthy volunteers or patients with asthma. However, in patients with asthma, bronchial cross-sectional areas were significantly smaller than in healthy volunteers, except after inhalation of salbutamol. Lung attenuation and anteroposterior attenuation gradient were significantly higher in patients with asthma than in healthy patients (P < .001). Air-trapping scores were significantly higher after methacholine challenge.

CONCLUSION: Helical thin-collimation CT at controlled lung volume and at full expiration associated with bronchial challenge may help evaluate bronchoreactivity and inflammation in mild intermittent asthma.

© RSNA, 2002

Index terms: Asthma, 68.754 • Lung, CT, 68.1211 • Lung, diseases, 68.754 • Lung, function, 68.754

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