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Cardiac Imaging |
1 From the Department of Clinical Radiology, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany (C.H., C.R.B., R.B., M.F.R.); Department of Radiology, Huazhong University of Science and Technology, Wuhan, People’s Republic of China (C.H.); and Siemens Medical Systems, Forchheim, Germany (B.O.). Received May 14, 2001; revision requested June 13; revision received August 27; accepted September 20. Address correspondence to C.R.B. (e-mail: christoph.becker@ikra.med.uni-muenchen.de).
PURPOSE: (a) To determine the accuracy of multi–detector row computed tomography (CT) in the measurement of the calcium concentration in a cardiac CT calibration phantom and (b) to assess the correlation of a traditional 3-mm section width CT coronary screening protocol and a 1.25-mm section width CT angiography imaging protocol in the quantification of the absolute mass of coronary calcium in patients who underwent both coronary screening and CT angiography with a multi–detector row CT scanner.
MATERIALS AND METHODS: A heart phantom containing calcified cylinders was scanned to determine calibration factors and absolute calcium mass. In 50 patients, the variability (value 1 - value 2/mean value 1 - value 2), limit of agreement (±2SD value 1 - value 2), and systematic error (mean value 1 - value 2) of the total amount of coronary calcium calculated at traditional 3-mm section width CT and at 1.25-mm section width CT angiography were determined.
RESULTS: The correlation coefficient between the 3-mm section width, nonenhanced protocol and the 1.25-mm section width CT angiography protocol was very high (r = 0.977) and the mean variability was low (19.7%) for the absolute mass. There was a systematic error of -6.7 mg and a limit of agreement between 45.0 mg and -58.5 mg.
CONCLUSION: Use of the mass quantification algorithm in combination with a calibration phantom allows accurate quantification of coronary calcium. Measurements of calcium mass obtained at 1.25-mm section width CT angiography have the best agreement with those obtained at the traditional 3-mm section width imaging protocol.
© RSNA, 2002
Index terms: Coronary vessels, calcification, 54.812 • Coronary vessels, CT, 54.12111, 54.12116 • Phantoms
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