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DOI: 10.1148/radiol.2232010482
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(Radiology 2002;223:554-557.)
© RSNA, 2002

Technical Developments

Measurement of Breast Density with Dual X-ray Absorptiometry: Feasibility1

John A. Shepherd, PhD, Karla M. Kerlikowske, MD, Rebecca Smith-Bindman, MD, Harry K. Genant, MD and Steve R. Cummings, MD

1 From the Department of Radiology, Osteoporosis and Arthritis Research Group (J.A.S., H.K.G.) and Department of Medicine and Epidemiology and Biostatistics (K.M.K., S.R.C.), University of California at San Francisco, 350 Parnassus Ave, Suite 607, San Francisco, CA 94143; Veterans Affairs Medical Center, San Francisco, Calif (K.M.K.); and Department of Radiology, UCSF/Mt Zion Medical Center, San Francisco, Calif (R.S.B.). From the 2000 RSNA scientific assembly. Received February 19, 2001; revision requested March 28; final revision received November 28; accepted December 10. Supported by Breast Cancer Research Program Concept Award DAMD17-00-1-0612 from the Department of Defense and by UCSF Academic Senate Committee on Research. Address correspondence to J.A.S. (e-mail: john.shepherd@oarg.ucsf.edu).

Dual x-ray absorptiometry (DXA) was used to quantify breast density with a phantom and with cadaveric breasts. With DXA, percentage of fat correlated with percentage of glandular density of the phantom (r > 0.998) and with density at mammography (radjusted = 0.83). DXA precision (SD) was 0.5% without and 1.1% with breast repositioning. DXA devices can be used to accurately and precisely estimate breast tissue density.

© RSNA, 2002

Index terms: Breast • Breast neoplasms, 00.30 • Cancer screening • Phantoms




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