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Technical Developments |
1 From the Department of Radiology, Neuroradiology Division, Johns Hopkins Hospital, 600 N Wolfe St, Phipps B-100, Baltimore, MD 21287-2182 (B.A.W.); the Laboratory of Cardiac Energetics (A.E.A, R.S.B.) and the Cardiology Branch (R.O.C.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; and the Departments of Pathology (W.I.S.) and Surgery (H.H.T.), Suburban Hospital, Bethesda, Md. Received March 22, 2001; revision requested May 1; revision received August 17; accepted September 17. Supported by the intramural program of the National Heart, Lung, and Blood Institute, protocol 98-H-0157. Address correspondence to B.A.W. (e-mail: bwasser@rad.jhu.edu).
In nine subjects with carotid atherosclerosis, double-oblique, contrast material–enhanced, double inversion-recovery, fast spin-echo magnetic resonance (MR) images were acquired through atheroma in the proximal internal carotid artery. Fibrocellular tissue within atheroma selectively enhanced 29% after administration of gadolinium-based contrast agent. Contrast enhancement helped discriminate fibrous cap from lipid core with a contrast-to-noise ratio as good as or better than that with T2-weighted MR images but with approximately twice the signal-to-noise ratio (postcontrast images, 36.6 ± 3.6; T2-weighted images, 17.5 ± 2.1; P < .001).
© RSNA, 2002
Index terms: Arteriosclerosis, 56.754, 9*.7212 • Magnetic resonance (MR), high-resolution, 56.121411, 9*.721 • Magnetic resonance (MR), tissue characterization, 56.121411, 9*.12916 • Magnetic resonance (MR), vascular studies, 9*.12916
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