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Breast Cancer: Regional Blood Flow and Blood Volume Measured with Magnetic Susceptibility–based MR Imaging—Initial Results¹

¹ From the Department of Radiology, NMR Center (J.P.D., L.G.) and Breast Imaging Center (P.J.S., E.D.Y., D.B.K.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass. Received February 7, 2001; revision requested April 3; revision received August 10; accepted November 30. Supported by the Massachusetts General Hospital NMR Center. Address correspondence to L.G., Instituto de Ciencia y Tecnología de Polímeros, C.S.I.C., Juan de la Cierva 3, 28006 Madrid, Spain (e-mail: lgarrido@cetef.csic.es).

The purpose of this study was to quantify microcirculation in breast neoplasms with magnetic susceptibility-based contrast material–enhanced magnetic resonance imaging. With this imaging method for invasive cancers, the mean values of the ratios of tumor to normal blood flow and blood volume were significantly higher (P < .002) than those for benign or normal tissue. The method allows independent measurement of regional blood flow and blood volume in breast cancers.

© RSNA, 2002

Index terms: Breast neoplasms, diagnosis, 00.32 • Breast neoplasms, MR, 00.121416 • Magnetic resonance (MR), perfusion study, 00.121416, 00.12144

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