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Neuroradiology |
1 From the Departments of Radiology (M.J.L., M.D.P., J.T.L., M.D., V.P.M.) and Neurology (D.M.), Indiana University School of Medicine, CL 157, 541 Clinical Dr, Indianapolis, IN 46202-5111. Received June 6, 2001; revision requested July 23; final revision received January 4, 2002; accepted January 15. Supported in part by a grant from the Whitaker Foundation. Address correspondence to M.J.L. (e-mail: mjlowe@iupui.edu).
PURPOSE: To study the correlation of low-frequency blood oxygenation level–dependent (BOLD) fluctuations on magnetic resonance (MR) images obtained of the left- and right-hemisphere primary motor regions in healthy control subjects and patients with multiple sclerosis (MS).
MATERIALS AND METHODS: Sixteen healthy volunteers and 20 patients with MS underwent MR imaging with a 1.5-T imager by using a protocol designed to monitor low-frequency BOLD fluctuations. Data for low-frequency BOLD fluctuations were acquired with subjects at rest and during continuous performance of a bilateral finger-tapping task. These data were low-pass filtered (<0.08 Hz), and cross correlations of all acquired pixels to a region of interest in the left precentral gyrus were calculated. Confidence levels were calculated from the cross correlations. The fraction of pixels in the right precentral gyrus above a confidence level of 95% for correlation with the left precentral gyrus was calculated for each subject.
RESULTS: A plot of the fraction of the right precentral gyrus with high correlation with the left precentral gyrus for the finger-tapping state versus the resting state showed a clear discrimination between patients with MS and control subjects. Compared with control subjects, patients with MS generally had a smaller fraction of the pixels in the right precentral gyrus above the confidence level. This finding indicates that our method results in greater than 60% sensitivity and 100% specificity for discriminating patients with MS from control subjects. No significant correlation was found between clinical measures of MS disease and correlations of low-frequency BOLD fluctuations between left and right precentral gyri.
CONCLUSION: On the basis of the connectivity measure of low-frequency BOLD fluctuations, patients with MS exhibited lower functional connectivity between right- and left-hemisphere primary motor cortices when compared with that in control subjects.
© RSNA, 2002
Index terms: Brain, MR, 10.121411, 10.121412, 10.121417 • Brain, white matter • Magnetic resonance (MR), magnetization transfer, 10.121412, 10.121417 • Sclerosis, multiple, 10.871
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