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Dementing Disorders: Volumetric Measurement of Cerebrospinal Fluid to Distinguish Normal from Pathologic Findings—Feasibility Study¹

¹ From the Division of Imaging Science and Biomedical Engineering, Medical School, University of Manchester, Oxford Rd, Manchester M13 9PT, England (N.A.T., S.S., A.J.); and Cognitive Function Unit, Central Manchester Healthcare Trust, Manchester, England (A.R.V., D.B., J.S.S., D.N.). Received February 5, 2001; revision requested March 26; revision received September 17; accepted January 7, 2002. Address correspondence to N.A.T. (e-mail: neil.thacker@man.ac.uk).

The authors describe a magnetic resonance (MR) imaging technique to quantify the severity and distribution of cerebral atrophy by using automated volumetric analysis of the distribution of cerebrospinal fluid. The MR imaging technique demonstrated high diagnostic sensitivity and specificity in a group of healthy subjects and patients with dementing diseases. The authors conclude that this approach provides valuable clinical information that is complementary to information acquired with standard diagnostic practices.

© RSNA, 2002

Index terms: Brain, atrophy, 13.83 • Brain, MR, 10.121411, 10.121412, 10.121419 • Dementia, 13.83 • Magnetic resonance (MR), image processing, 10.12144, 10.12149 • Magnetic resonance (MR), three-dimensional, 10.121419

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