HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Manfredi, R. Articles by Marano, P. Search for Related Content PubMed PubMed Citation Articles by Manfredi, R. Articles by Marano, P.

Idiopathic Chronic Pancreatitis in Children: MR Cholangiopancreatography after Secretin Administration¹

¹ From the Departments of Radiology (R.M., B.G., M.G.B., A.V., G.M., P.M.) and Endoscopic Surgery (G.C.), A. Gemelli University Hospital, 8 Largo A. Gemelli, Rome 00168, Italy; and Departments of Gastroenterology (V.L.) and Endoscopic Surgery (L.D.), Bambino Gesù Children’s Hospital, Rome, Italy. From the 2000 RSNA scientific assembly. Received June 20, 2001; revision requested August 15; revision received November 5; accepted March 25, 2002. Address correspondence to R.M. (e-mail: rmanfredi@rm.unicatt.it).

PURPOSE: To assess the accuracy of dynamic magnetic resonance (MR) cholangiopancreatography after secretin administration in detecting pancreatic duct abnormalities typical of early-onset idiopathic chronic pancreatitis in children with recurrent episodes of idiopathic acute pancreatitis.

MATERIALS AND METHODS: Fifteen children (mean age, 11.3 years; range, 6–17 years) with at least three recurrent episodes of idiopathic acute pancreatitis prospectively underwent MR cholangiopancreatography before and after secretin administration. Image analysis included visualization of side branches, ductal narrowing, endoluminal filling defects, irregular ductal contour, cavities, and pancreas divisum. All patients underwent endoscopic retrograde cholangiopancreatography (ERCP).

RESULTS: Dilated side branches were detected in three (20%) of 15 patients on MR cholangiopancreatograms obtained before secretin administration and in seven (47%) of 15 patients on images obtained after secretin administration. Ductal narrowing was detected in one (7%) of 15 patients on images obtained before secretin administration and in two (13%) of 15 patients on images obtained after secretin administration. Endoluminal filling defects in one (7%) of 15 patients were observed on MR cholangiopancreatograms obtained both before and after secretin administration. Irregular contour of the main pancreatic duct was present in four (27%) of 15 patients on MR cholangiopancreatograms obtained before secretin administration and in five (33%) of 15 patients on images obtained after secretin administration. Cavities and pancreas divisum were detected in one (7%) of 15 patients and in two (13%) of 15 patients, respectively, only on MR cholangiopancreatograms obtained after secretin administration.

CONCLUSION: Secretin improves the sensitivity of MR cholangiopancreatography in diagnosing early-onset idiopathic chronic pancreatitis.

© RSNA, 2002

Index terms: Bile ducts, MR, 774.12141 • Children, gastrointestinal system, 77.291 • Endoscopic retrograde cholangiopancreatography (ERCP), 774.1222 • Magnetic resonance (MR), cholangiopancreatography, 774.12141 • Pancreatitis, 77.291

This article has been cited by other articles:

				E M ARMSTRONG, D J M TOLAN, C S VERBEKE, and M B SHERIDAN Evolution of idiopathic fibrosing pancreatitis -- MRI features Br. J. Radiol., September 1, 2008; 81(969): e225 - e227. [Abstract] [Full Text] [PDF]

				R. Tamura, T. Ishibashi, and S. Takahashi Chronic Pancreatitis: MRCP versus ERCP for Quantitative Caliber Measurement and Qualitative Evaluation Radiology, March 1, 2006; 238(3): 920 - 928. [Abstract] [Full Text] [PDF]

				J. Monill, J. Pernas, J. Clavero, A. Farre, A. Morales, M. Gonzalez, V. Artigas, and A. Martinez-Noguera Pancreatic Duct After Pancreatoduodenectomy: Morphologic and Functional Evaluation with Secretin-Stimulated MR Pancreatography Am. J. Roentgenol., November 1, 2004; 183(5): 1267 - 1274. [Abstract] [Full Text] [PDF]