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Evolution of a Protocol for Ketamine-induced Sedation as an Alternative to General Anesthesia for Interventional Radiologic Procedures in Pediatric Patients¹

¹ From the Departments of Anesthesia (K.P.M., J.A.D.), Radiology (K.P.M., V.E.K., L.C., P.E.B.), and Biostatistics (D.Z.), The Children’s Hospital, 300 Longwood Ave, Boston, MA 02115-5737; and Department of Anesthesia, Brigham and Women’s Hospital, Boston, Mass (E.M.). From the 2001 RSNA scientific assembly. Received November 5, 2001; revision requested December 3; revision received February 26, 2002; accepted April 2. Address correspondence to K.P.M. (e-mail: keira.mason@tch.harvard.edu).

PURPOSE: To establish a protocol for credentialed pediatric radiology nurses, with radiologist supervision, to administer ketamine to induce sedation and analgesia during interventional radiologic procedures.

MATERIALS AND METHODS: This study was conducted in two phases. The goal of the first phase was to develop a sedation protocol to replace that of using general anesthesia for specified pediatric interventional procedures. Ketamine was administered intravenously (with intermittent bolus or continuous infusion) or intramuscularly. Sedation induction times, adverse events, doses, and sedation and recovery durations were recorded. In phase 2, the results of phase 1 were reviewed and a formal ketamine protocol was developed.

RESULTS: Neither sedation failures nor substantial adverse events occurred in phase 1. Mean duration of all sedations was 52 minutes, and median recovery room time was 0 minutes. In phase 2, the results of phase 1 were reviewed and a sedation protocol was proposed to a hierarchy of hospital committees before final approval from the medical staff executive committee. Subsequently, standard order forms for radiology nurse administration of ketamine with radiologist supervision were prepared for exclusive use by the pediatric interventional radiology department.

CONCLUSION: Ketamine-induced sedation may be a safe and effective alternative to general anesthesia for some interventional radiologic procedures in pediatric patients. Collaboration between anesthesia and radiology departments is important for development of a safe and successful ketamine sedation program. To the authors’ knowledge, this is the first report describing the intravenous infusion of ketamine for sedation in pediatric patients and the only report describing the establishment of a protocol for ketamine administration by credentialed radiology nurses with radiologist supervision.

© RSNA, 2002

Index terms: Anesthesia • Interventional procedures, in infants and children, _**.126²

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