Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print November 21, 2002, 10.1148/radiol.2261011904
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2261011904v1
226/1/71    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taouli, B.
Right arrow Articles by Menu, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taouli, B.
Right arrow Articles by Menu, Y.
(Radiology 2003;226:71-78.)
© RSNA, 2002

Gastrointestinal Imaging

Evaluation of Liver Diffusion Isotropy and Characterization of Focal Hepatic Lesions with Two Single-Shot Echo-planar MR Imaging Sequences: Prospective Study in 66 Patients1

Bachir Taouli, MD, Valérie Vilgrain, MD, Erik Dumont, PhD, Jean-Luc Daire, PhD, Bo Fan, MD and Yves Menu, MD

1 From the Department of Radiology, Hôpital Beaujon and Laboratoire d’Imagerie Médicale Paris-Nord, Faculté de Médecine Paris VII, Clichy, France (B.T., V.V., E.D., J.L.D., Y.M.); and Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Rm M-372, Box 0628, San Francisco, CA 94143 (B.T., B.F.). From the 2001 RSNA scientific assembly. Received November 27, 2001; revision requested February 7, 2002; revision received March 15; accepted May 7. Supported by a grant from the French Radiology Society. Address correspondence to B.T. (e-mail: bachir.taouli@radiology.ucsf.edu).

PURPOSE: To (a) evaluate liver diffusion isotropy, (b) compare two diffusion-weighted magnetic resonance (MR) imaging sequences for the characterization of focal hepatic lesions by using two or four b values, and (c) determine an apparent diffusion coefficient (ADC) threshold value to differentiate benign from malignant lesions.

MATERIALS AND METHODS: Sixty-six patients were examined with two single-shot echo-planar diffusion-weighted MR sequences. In the first sequence, liver diffusion isotropy was evaluated by using diffusion gradients in three directions with two b values. In the second sequence, a unidirectional diffusion gradient was used with four b values. ADCs were measured in 43 patients with 52 focal hepatic lesions more than 1 cm in diameter and in 23 patients with 14 normal and nine cirrhotic livers and were compared by using nonparametric tests.

RESULTS: Diffusion in the liver parenchyma was isotropic. ADCs of focal hepatic lesions were significantly different between sequences (P < .01). The mean (± SD) ADCs in the first sequence were 0.94 x 10-3 mm2/sec ± 0.60 for metastases, 1.33 x 10-3 mm2/sec ± 0.13 for HCCs, 1.75 x 10-3 mm2/sec ± 0.46 for benign hepatocellular lesions, 2.95 x 10-3 mm2/sec ± 0.67 for hemangiomas, and 3.63 x 10-3 mm2/sec ± 0.56 for cysts. There was a significant difference between benign (2.45 x 10-3 mm2/sec ± 0.96, isotropic value) and malignant (1.08 x 10-3 mm2/sec ± 0.50) lesions (P < .01 for both sequences).

CONCLUSION: Diffusion-weighted MR imaging can help differentiate benign from malignant hepatic lesions. The use of two b values in one direction could be sufficient for the design of MR sequences in the liver.

© RSNA, 2002

Index terms: Liver, diseases, 761.30, 761.79 • Liver, focal nodular hyperplasia, 761.3198 • Liver neoplasms, 761.30 • Liver neoplasms, MR, 761.121416, 761.12144 • Magnetic resonance (MR), diffusion study, 761.12144 • Magnetic resonance (MR), echo planar, 761.121416




This article has been cited by other articles:


Home page
 Am. J. Roentgenol.Home page
B. Taouli, R. L. Ehman, and S. B. Reeder
Advanced MRI Methods for Assessment of Chronic Liver Disease
Am. J. Roentgenol., July 1, 2009; 193(1): 14 - 27.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. Uto, Y. Takehara, Y. Nakamura, T. Naito, D. Hashimoto, N. Inui, T. Suda, H. Nakamura, and K. Chida
Higher Sensitivity and Specificity for Diffusion-weighted Imaging of Malignant Lung Lesions without Apparent Diffusion Coefficient Quantification
Radiology, July 1, 2009; 252(1): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. Chandarana and V. S. Lee
Renal Functional MRI: Are We Ready for Clinical Application?
Am. J. Roentgenol., June 1, 2009; 192(6): 1550 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Kim, M. Jain, A. B. Harris, V. S. Lee, J. S. Babb, E. E. Sigmund, L. E. Rueff, and B. Taouli
T1 Hyperintense Renal Lesions: Characterization with Diffusion-weighted MR Imaging versus Contrast-enhanced MR Imaging
Radiology, June 1, 2009; 251(3): 796 - 807.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. Watanabe, M. Kanematsu, H. Kondo, S. Goshima, Y. Tsuge, M. Onozuka, and N. Moriyama
Preoperative T Staging of Urinary Bladder Cancer: Does Diffusion-Weighted MRI Have Supplementary Value?
Am. J. Roentgenol., May 1, 2009; 192(5): 1361 - 1366.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
B. Taouli, R. K. Thakur, L. Mannelli, J. S. Babb, S. Kim, E. M. Hecht, V. S. Lee, and G. M. Israel
Renal Lesions: Characterization with Diffusion-weighted Imaging versus Contrast-enhanced MR Imaging
Radiology, May 1, 2009; 251(2): 398 - 407.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. E. Abou-El-Ghar, A. El-Assmy, H. F. Refaie, and T. El-Diasty
Bladder Cancer: Diagnosis with Diffusion-weighted MR Imaging in Patients with Gross Hematuria
Radiology, May 1, 2009; 251(2): 415 - 421.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. Kandpal, R. Sharma, K. S. Madhusudhan, and K. S. Kapoor
Respiratory-Triggered Versus Breath-Hold Diffusion-Weighted MRI of Liver Lesions: Comparison of Image Quality and Apparent Diffusion Coefficient Values
Am. J. Roentgenol., April 1, 2009; 192(4): 915 - 922.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Takeuchi, S. Sasaki, M. Ito, S. Okada, S. Takahashi, T. Kawai, K. Suzuki, H. Oshima, M. Hara, and Y. Shibamoto
Urinary Bladder Cancer: Diffusion-weighted MR Imaging--Accuracy for Diagnosing T Stage and Estimating Histologic Grade
Radiology, April 1, 2009; 251(1): 112 - 121.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. Luciani, A. Vignaud, M. Cavet, J. Tran Van Nhieu, A. Mallat, L. Ruel, A. Laurent, J.-F. Deux, P. Brugieres, and A. Rahmouni
Liver Cirrhosis: Intravoxel Incoherent Motion MR Imaging--Pilot Study
Radiology, December 1, 2008; 249(3): 891 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. Bruegel, J. Gaa, S. Waldt, K. Woertler, K. Holzapfel, B. Kiefer, and E. J. Rummeny
Diagnosis of Hepatic Metastasis: Comparison of Respiration-Triggered Diffusion-Weighted Echo-Planar MRI and Five T2-Weighted Turbo Spin-Echo Sequences
Am. J. Roentgenol., November 1, 2008; 191(5): 1421 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
Y. Cui, X.-P. Zhang, Y.-S. Sun, L. Tang, and L. Shen
Apparent Diffusion Coefficient: Potential Imaging Biomarker for Prediction and Early Detection of Response to Chemotherapy in Hepatic Metastases
Radiology, September 1, 2008; 248(3): 894 - 900.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
N. I. Sainani, O. A. Catalano, N.-S. Holalkere, A. X. Zhu, P. F. Hahn, and D. V. Sahani
Cholangiocarcinoma: Current and Novel Imaging Techniques
RadioGraphics, September 1, 2008; 28(5): 1263 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
I. C. van den Bos, S. M. Hussain, G. P. Krestin, and P. A. Wielopolski
Liver Imaging at 3.0 T: Diffusion-induced Black-Blood Echo-planar Imaging with Large Anatomic Volumetric Coverage as an Alternative for Specific Absorption Rate-intensive Echo-Train Spin-Echo Sequences: Feasibility Study
Radiology, July 1, 2008; 248(1): 264 - 271.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. Zhang, Y. Mazaheri Tehrani, L. Wang, N. M. Ishill, L. H. Schwartz, and H. Hricak
Renal Masses: Characterization with Diffusion-weighted MR Imaging--A Preliminary Experience
Radiology, May 1, 2008; 247(2): 458 - 464.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
R. F. Hanna, D. A. Aguirre, N. Kased, S. C. Emery, M. R. Peterson, and C. B. Sirlin
Cirrhosis-associated Hepatocellular Nodules: Correlation of Histopathologic and MR Imaging Features
RadioGraphics, May 1, 2008; 28(3): 747 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
C. G. Lall, A. M. Aisen, N. Bansal, and K. Sandrasegaran
Nonalcoholic Fatty Liver Disease
Am. J. Roentgenol., April 1, 2008; 190(4): 993 - 1002.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. Parikh, S. J. Drew, V. S. Lee, S. Wong, E. M. Hecht, J. S. Babb, and B. Taouli
Focal Liver Lesion Detection and Characterization with Diffusion-weighted MR Imaging: Comparison with Standard Breath-hold T2-weighted Imaging
Radiology, March 1, 2008; 246(3): 812 - 822.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
S.-H. Shen, Y.-Y. Chiou, J.-H. Wang, M.-S. Yen, R.-C. Lee, C.-R. Lai, and C.-Y. Chang
Diffusion-Weighted Single-Shot Echo-Planar Imaging with Parallel Technique in Assessment of Endometrial Cancer
Am. J. Roentgenol., February 1, 2008; 190(2): 481 - 488.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
N. Inan, A. Arslan, G. Akansel, Y. Anik, H. T. Sarisoy, E. Ciftci, and A. Demirci
Diffusion-Weighted Imaging in the Differential Diagnosis of Simple and Hydatid Cysts of the Liver
Am. J. Roentgenol., November 1, 2007; 189(5): 1031 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
B. Taouli, A. J. Tolia, M. Losada, J. S. Babb, E. S. Chan, M. A. Bannan, and H. Tobias
Diffusion-Weighted MRI for Quantification of Liver Fibrosis: Preliminary Experience
Am. J. Roentgenol., October 1, 2007; 189(4): 799 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D.-M. Koh and D. J. Collins
Diffusion-Weighted MRI in the Body: Applications and Challenges in Oncology
Am. J. Roentgenol., June 1, 2007; 188(6): 1622 - 1635.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Matoba, H. Tonami, T. Kondou, H. Yokota, K. Higashi, H. Toga, and T. Sakuma
Lung Carcinoma: Diffusion-weighted MR Imaging--Preliminary Evaluation with Apparent Diffusion Coefficient
Radiology, May 1, 2007; 243(2): 570 - 577.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
D.-M. Koh, E. Scurr, D. Collins, B. Kanber, A. Norman, M. O. Leach, and J. E. Husband
Predicting Response of Colorectal Hepatic Metastasis: Value of Pretreatment Apparent Diffusion Coefficients
Am. J. Roentgenol., April 1, 2007; 188(4): 1001 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
T. Yoshikawa, H. Kawamitsu, D. G. Mitchell, Y. Ohno, Y. Ku, Y. Seo, M. Fujii, and K. Sugimura
ADC measurement of abdominal organs and lesions using parallel imaging technique.
Am. J. Roentgenol., December 1, 2006; 187(6): 1521 - 1530.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
C.-Y. Chen, C.-W. Li, Y.-T. Kuo, T.-S. Jaw, D.-K. Wu, J.-C. Jao, J.-S. Hsu, and G.-C. Liu
Early Response of Hepatocellular Carcinoma to Transcatheter Arterial Chemoembolization: Choline Levels and MR Diffusion Constants--Initial Experience
Radiology, May 1, 2006; 239(2): 448 - 456.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
H. C. Thoeny, F. De Keyzer, R. H. Oyen, and R. R. Peeters
Diffusion-weighted MR Imaging of Kidneys in Healthy Volunteers and Patients with Parenchymal Diseases: Initial Experience
Radiology, June 1, 2005; 235(3): 911 - 917.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
H. C. Thoeny, F. De Keyzer, F. Chen, Y. Ni, W. Landuyt, E. K. Verbeken, H. Bosmans, G. Marchal, and R. Hermans
Diffusion-weighted MR Imaging in Monitoring the Effect of a Vascular Targeting Agent on Rhabdomyosarcoma in Rats
Radiology, March 1, 2005; 234(3): 756 - 764.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
B. Taouli, A. J. Martin, A. Qayyum, R. B. Merriman, D. Vigneron, B. M. Yeh, and F. V. Coakley
Parallel Imaging and Diffusion Tensor Imaging for Diffusion-Weighted MRI of the Liver: Preliminary Experience in Healthy Volunteers
Am. J. Roentgenol., September 1, 2004; 183(3): 677 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
I. R. Kamel, D. A. Bluemke, D. Ramsey, M. Abusedera, M. Torbenson, J. Eng, G. Szarf, and J.-F. Geschwind
Role of Diffusion-Weighted Imaging in Estimating Tumor Necrosis After Chemoembolization of Hepatocellular Carcinoma
Am. J. Roentgenol., September 1, 2003; 181(3): 708 - 710.
[Full Text] [PDF]