| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
State of the Art |
1 From the Departments of Radiology (J.R.P., R.E.C.) and Geriatric Medicine and Psychiatry (P.M.D.), Duke University Medical Center, Duke Hospital North, Rm 1513, Erwin Rd, Durham, NC 27710. Received September 28, 2001; revision requested December 3; revision received February 25, 2002; accepted March 14. J.R.P. supported by grants from the RSNA Research and Education Foundation and the National Institute of Aging (R01AG019728-01). P.M.D. supported by grants from the American Federation of Aging Research and the National Institutes of Health. Address correspondence to J.R.P. (e-mail: jeffrey.petrella@duke.edu).
Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. Current consensus statements have emphasized the need for early recognition and the fact that a diagnosis of AD can be made with high accuracy by using clinical, neuropsychologic, and imaging assessments. Magnetic resonance (MR) or computed tomographic (CT) imaging is recommended for the routine evaluation of AD. Coronal MR images can be useful to document or quantify atrophy of the hippocampus and entorhinal cortex, both of which occur early in the disease process. Both volumetric and subtraction MR techniques can be used to quantify and monitor dementia progression and rates of regional atrophy. MR measures are also increasingly being used to monitor treatment effects in clinical trials of cognitive enhancers and antidementia agents. Positron emission tomography (PET) and single photon emission CT offer value in the differential diagnosis of AD from other cortical and subcortical dementias and may also offer prognostic value. In addition, PET studies have demonstrated that subtle abnormalities may be apparent in the prodromal stages of AD and in subjects who carry susceptibility genes. PET ligands are in late-stage development for demonstration of amyloid plaques, and human studies have already begun. Functional MR–based memory challenge tests are in development as well.
© RSNA, 2003
Index terms: Alzheimer disease, 13.83 • Brain, CT, 13.12111 • Brain, function • Brain, MR, 13.121411, 13.121412, 13.121416, 13.12144, 13.12145 • Brain, radionuclide studies, 13.12162, 13.12163 • State of the Art
This article has been cited by other articles:
|
|
 |
|
  D. B. Parente, E. L. Gasparetto, L. C. H. d. Cruz Jr., R. C. Domingues, A. C. Baptista, A. C. P. Carvalho, and R. C. Domingues Potential Role of Diffusion Tensor MRI in the Differential Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease Am. J. Roentgenol., May 1, 2008; 190(5): 1369 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Matsunari, M. Samuraki, W.-P. Chen, D. Yanase, N. Takeda, K. Ono, M. Yoshita, H. Matsuda, M. Yamada, and S. Kinuya Comparison of 18F-FDG PET and Optimized Voxel-Based Morphometry for Detection of Alzheimer's Disease: Aging Effect on Diagnostic Performance J. Nucl. Med., December 1, 2007; 48(12): 1961 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Hammoud, J. M. Hoffman, and M. G. Pomper Molecular Neuroimaging: From Conventional to Emerging Techniques Radiology, October 1, 2007; 245(1): 21 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Foster, J. L. Heidebrink, C. M. Clark, W. J. Jagust, S. E. Arnold, N. R. Barbas, C. S. DeCarli, R. Scott Turner, R. A. Koeppe, R. Higdon, et al. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease Brain, October 1, 2007; 130(10): 2616 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A D MURRAY Imaging in dementia Imaging, June 1, 2007; 19(2): 133 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Doraiswamy, G. J. Gilbert, G. W. Small, V. Kepe, and J. R. Barrio PET Scanning in Mild Cognitive Impairment N. Engl. J. Med., March 15, 2007; 356(11): 1175 - 1176. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Minati, M. Grisoli, and M. G. Bruzzone MR Spectroscopy, Functional MRI, and Diffusion-Tensor Imaging in the Aging Brain: A Conceptual Review J Geriatr Psychiatry Neurol, March 1, 2007; 20(1): 3 - 21. [Abstract] [PDF]
|
|
|
|
 |
|
 M. C MONTALTO, G. FARRAR, and C. T. HEHIR Fibrillar and Oligomeric beta-Amyloid as Distinct Local Biomarkers for Alzheimer's Disease Ann. N.Y. Acad. Sci., February 1, 2007; 1097(1): 239 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, N. Schuff, G. -H. Jahng, W. Bayne, S. Mori, L. Schad, S. Mueller, A. -T. Du, J. H. Kramer, K. Yaffe, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease Neurology, January 2, 2007; 68(1): 13 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S.C. Korf, L. R. White, P. Scheltens, and L. J. Launer Brain Aging in Very Old Men With Type 2 Diabetes: The Honolulu-Asia Aging Study Diabetes Care, October 1, 2006; 29(10): 2268 - 2274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ramani, J. H. Jensen, and J. A. Helpern Quantitative MR Imaging in Alzheimer Disease Radiology, October 1, 2006; 241(1): 26 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.L. Giesel, H.K. Hahn, P.A. Thomann, E. Widjaja, E. Wignall, H. von Tengg-Kobligk, J. Pantel, P.D. Griffiths, H.O. Peitgen, J. Schroder, et al. Temporal Horn Index and Volume of Medial Temporal Lobe Atrophy Using a New Semiautomated Method for Rapid and Precise Assessment AJNR Am. J. Neuroradiol., August 1, 2006; 27(7): 1454 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Petrella, S. Krishnan, M. J. Slavin, T.-T. T. Tran, L. Murty, and P. M. Doraiswamy Mild Cognitive Impairment: Evaluation with 4-T Functional MR Imaging Radiology, July 1, 2006; 240(1): 177 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Johnson, G.-H. Jahng, M. W. Weiner, B. L. Miller, H. C. Chui, W. J. Jagust, M. L. Gorno-Tempini, and N. Schuff Pattern of Cerebral Hypoperfusion in Alzheimer Disease and Mild Cognitive Impairment Measured with Arterial Spin-labeling MR Imaging: Initial Experience Radiology, March 1, 2005; 234(3): 851 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Doraiswamy, D. C. Steffens, and D. R. Mcquoid Statin use and hippocampal volumes in elderly subjects at risk for Alzheimer's disease: A pilot observational study American Journal of Alzheimer's Disease and Other Dementias, September 1, 2004; 19(5): 275 - 278. [Abstract] [PDF]
|
|
|
|
|
|
R. N. Bryan The Digital rEvolution: The Millennial Change in Medical Imaging Radiology, November 1, 2003; 229(2): 299 - 304. [Full Text] [PDF]
|
|
|
|
 |
|
 G B Frisoni, P h Scheltens, S Galluzzi, F M Nobili, N C Fox, P H Robert, H Soininen, L-O Wahlund, G Waldemar, and E Salmon Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC J. Neurol. Neurosurg. Psychiatry, October 1, 2003; 74(10): 1371 - 1381. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
