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Experimental Studies |
1 From the Department of Radiology-MRI, Bolwell B 124, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106 (F.K.W., M.W., J.S.L.); Department of Radiology, Benjamin Franklin University Hospital, Free University, Berlin, Germany (F.K.W., K.R., K.J.W.); Schering, Berlin, Germany (W.E.); and Siemens, Erlangen, Germany (M.W.). From the 2000 RSNA scientific assembly. Received November 12, 2001; revision requested January 28, 2002; final revision received May 1; accepted June 5. Supported by grants R33 CA88144-01 and R01 CA81431-02 from the National Cancer Institute and grants from Siemens Medical Solutions. Address correspondence to F.K.W. (e-mail: wackerfrank@web.de).
PURPOSE: To evaluate the feasibility of using the ultrasmall superparamagnetic iron oxide (USPIO) SH U 555 C as an intravascular contrast agent for magnetic resonance (MR) image–guided vascular procedures with an open MR imaging system.
MATERIALS AND METHODS: All experiments were performed with MR imaging at 0.2 T. MR image–guided interventions were performed in USPIO-enhanced vessels in four pigs. With near real-time MR image guidance (acquisition time, 0.64 second per section), the splenic and renal arteries were consecutively catheterized by using a susceptibility artifact–based catheter–guide wire combination. Angioplasty and stent implantation were performed four times in the renal artery and twice in the iliac artery. Intraaortal signal intensity (SI) was measured during the interventions.
RESULTS: After administration of SH U 555 C (40 µmol of iron per kilogram of body weight), a three-dimensional MR angiographic sequence was performed that allowed visualization of the abdominal and pelvic vessels that were as small as 2 mm in diameter. Catheterization, angioplasty, and stent implantation were successfully guided in the USPIO-enhanced vasculature. Sixty minutes after contrast agent injection, the mean aortic SI was 70% of the maximum measured enhancement levels.
CONCLUSION: One intravenous injection of SH U 555 C enabled long, continuous intravascular SI enhancement at MR angiography, and, in combination with susceptibility artifact–based device tracking, the injection allowed the performance of MR imaging–guided intravascular interventions in an open MR imaging system.
© RSNA, 2003
Index terms: Animals • Interventional procedures, experimental studies, 954.1268, 961.1268, 988.1268 • Magnetic resonance (MR), contrast media, 954.129412, 954.12943, 961.129412, 961.12943, 988.129412, 988.12943 • Magnetic resonance (MR), vascular studies, 954.129412, 954.12943, 961.129412, 961.12943, 988.129412, 988.12943 • Stents and prostheses, 961.1286
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