Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print February 28, 2003, 10.1148/radiol.2271012173
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2271012173v1
227/1/129    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Field, A. S.
Right arrow Articles by Moody, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Field, A. S.
Right arrow Articles by Moody, D. M.
(Radiology 2003;227:129-135.)
© RSNA, 2003

Neuroradiology

Dietary Caffeine Consumption and Withdrawal: Confounding Variables in Quantitative Cerebral Perfusion Studies?1

Aaron S. Field, MD, PhD, Paul J. Laurienti, MD, PhD, Yi-Fen Yen, PhD, Jonathan H. Burdette, MD and Dixon M. Moody, MD

1 From the Division of Radiological Sciences, Wake Forest University School of Medicine, Winston-Salem, NC. From the 2001 RSNA scientific assembly. Received January 17, 2002; revision requested February 27; final revision received August 5; accepted August 19. Supported in part by a grant from the Charles A. Dana Foundation. Address correspondence to A.S.F., Department of Radiology, University of Wisconsin Medical School, 600 Highland Ave, Module E3/311, Madison, WI 53792-3252 (e-mail: asfield@wisc.edu).

PURPOSE: To evaluate the effects of dietary caffeine intake and withdrawal on cerebral blood flow (CBF), as determined from a randomized, blinded, placebo-controlled study.

MATERIALS AND METHODS: Twenty adults (16 men, four women; age range, 24-64 years) categorized as low (mean, 41 mg/d) or high (mean, 648 mg/d) caffeine users underwent quantitative flow-sensitive alternating inversion-recovery perfusion magnetic resonance (MR) imaging twice: 90 minutes after a dose of caffeine (250 mg) on one day and after a dose of placebo on another day (randomized counterbalanced design). Doses were preceded by 30 hours of caffeine abstinence to induce withdrawal in high caffeine users. Quantitative CBF maps were gray matter (GM)–white matter (WM) segmented and subjected to region-of-interest analysis to obtain mean CBF in WM, anterior circulation GM (AGM), and posterior circulation GM (PGM). By using two-way repeated-measures analysis of variance, regional CBF data were tested for within-subject differences between caffeine and placebo and for between-subject differences related to dietary caffeine habits. Linear regression was used to determine whether dietary caffeine use predicts CBF or CBF response to caffeine.

RESULTS: Caffeine reduced CBF (P <= .05) by 23% (AGM, PGM) and 18% (WM) in all subjects. Postplacebo (withdrawal) CBF in high caffeine users exceeded that in low users (P <= .05) by 31% (AGM) and 32% (WM) (PGM, not significant). Mean postcaffeine CBF reduction in AGM was 26% in high users versus 19% in low users (P <= .05; PGM and WM, not significant). Increasing caffeine consumption predicted higher CBF (P <= .05) in all regions: r = 0.79 (AGM), 0.57 (PGM), and 0.76 (WM). Dietary caffeine use did not predict CBF response to caffeine.

CONCLUSION: Dietary caffeine consumption and withdrawal are potential confounding variables in cerebral perfusion and functional MR imaging.

© RSNA, 2003

Index terms: Brain, perfusion, 10.12144 • Drugs, side effects • Magnetic resonance (MR), perfusion study, 10.12144




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
A.R. Deibler, J.M. Pollock, R.A. Kraft, H. Tan, J.H. Burdette, and J.A. Maldjian
Arterial Spin-Labeling in Routine Clinical Practice, Part 2: Hypoperfusion Patterns
AJNR Am. J. Neuroradiol., August 1, 2008; 29(7): 1235 - 1241.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. Waaijer, M. S. van Leeuwen, M. J.P. van Osch, B. H. van der Worp, F. L. Moll, R. T. H. Lo, W. P. T. M. Mali, and M. Prokop
Changes in Cerebral Perfusion after Revascularization of Symptomatic Carotid Artery Stenosis: CT Measurement
Radiology, November 1, 2007; 245(2): 541 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
C Hoecker, M Nelle, B Beedgen, J Rengelshausen, and O Linderkamp
Effects of a divided high loading dose of caffeine on circulatory variables in preterm infants
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2006; 91(1): F61 - F64.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. Hendrikse, M. J. P. van Osch, D. R. Rutgers, C. J. G. Bakker, L. J. Kappelle, X. Golay, and J. van der Grond
Internal Carotid Artery Occlusion Assessed at Pulsed Arterial Spin-labeling Perfusion MR Imaging at Multiple Delay Times
Radiology, December 1, 2004; 233(3): 899 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
P. J. Laurienti, A. S. Field, J. H. Burdette, J. A. Maldjian, Y.-F. Yen, and D. M. Moody
Relationship between Caffeine-Induced Changes in Resting Cerebral Perfusion and Blood Oxygenation Level-Dependent Signal
AJNR Am. J. Neuroradiol., September 1, 2003; 24(8): 1607 - 1611.
[Abstract] [Full Text] [PDF]