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Dynamic Three-dimensional MR Renography for the Measurement of Single Kidney Function: Initial Experience¹

¹ From the Department of Radiology-MRI, New York University Medical Center, 530 First Ave, HCC Basement, New York, NY 10016. From the 2001 RSNA scientific assembly. Received April 8, 2002; revision requested June 17; revision received June 28; accepted August 8. Supported by an RSNA Research and Education Foundation Seed Grant, National Institutes of Health K23-DK02814 grant, and Society of Computed Body Tomography/Magnetic Resonance Lauterbur and Junior Investigator Awards. Address correspondence to V.S.L. (e-mail: vivian.lee@med.nyu.edu).

A three-dimensional magnetic resonance (MR) renographic method to measure single kidney glomerular filtration rate (GFR) and split renal function was developed that is based on renal signal intensity measurements during 2–3 minutes after intravenous injection of a low dose (2 mL or 0.01 mmol/kg) of gadopentetate dimeglumine. In nine subjects, single kidney MR GFR indices correlated well with technetium 99m (^99mTc) diethylenetriaminepentaacetic acid (DTPA) clearance (r = 0.7–0.8) for GFR values of 7–48 mL/min. MR right kidney split renal function values (range, 32%–59%) also correlated well with ^99mTc-DTPA radionuclide measurements (r = 0.76); differences between the two methods averaged 0.8% ± 8. MR renography was performed along with contrast material–enhanced MR imaging of the kidneys and renal arteries and added 8 minutes or less to the total examination time.

© RSNA, 2003

Index terms: Kidney, function, 81.91 • Kidney, perfusion, 961.12943 • Magnetic resonance (MR), contrast enhancement, 81.12143 • Magnetic resonance (MR), perfusion study, 961.12943

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