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Sickle Cell Disease: Continuous Arterial Spin-labeling Perfusion MR Imaging in Children¹

¹ From the Depts of Radiology and Radiological Sciences (K.K.O., X.G., F.B.P., N.W., P.C.M.v.Z., E.R.M.) and Pediatrics, Div of Pediatric Hematology (C.A.F., J.F.C.), Johns Hopkins Med Insts, Baltimore, Md; F. M. Kirby Research Ctr for Functional Brain Imaging, Kennedy-Krieger Inst, Baltimore, Md (K.K.O., X.G., F.B.P., P.C.M.v.Z., E.R.M.); and Dept of Pediatrics and Neurology, Children’s Hosp of Philadelphia and Univ of Pennsylvania (R.I.). Received Jul 24, 2002; revision requested Sep 26; revision received Oct 11; accepted Dec 10. Supported by NIH grant R21-0035-01. Address correspondence to E.R.M., Dept of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (e-mail: emelhem@rad.upen.edu).

Cerebral blood flow (CBF) was measured with continuous arterial spin-labeling perfusion magnetic resonance (MR) imaging in 14 children with sickle cell disease and seven control subjects. Mean CBF values were higher in patients (P < .005) than in control subjects in all cerebral artery territories. Three patients had decreased CBF in right anterior and middle cerebral artery territories compared with CBF on the left, and one patient had a profound decrease in CBF in all three territories in the right hemisphere. Baseline CBF was significantly decreased in territories seen as unaffected on conventional MR images and MR angiograms in four children with sickle cell disease.

© RSNA, 2003

Index terms: Magnetic resonance (MR), in infants and children • Magnetic resonance (MR), perfusion study, 17.121416, 17.14144 • Cerebral blood vessels, flow dynamics, 173.781, 174.781, 1756.781 • Cerebral blood vessels, MR, 17.121411, 17.121413, 17.121416, 17.12142, 17.12144 • Sickle cell disease (SS, SC), 17.651

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