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Published online before print June 23, 2003, 10.1148/radiol.2282020907
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(Radiology 2003;228:560-568.)
© RSNA, 2003

Technical Developments

Functional Genomics Guided with MR Imaging: Mouse Tumor Model Study1

Samira Guccione, PhD, Yi-Shan Yang, PhD, Gongyi Shi, PhD, Daniel Y. Lee, MD, PhD, King C. P. Li, MD, FRCPC2 and Mark D. Bednarski, PhD

1 From the Lucas MR Spectroscopy and Imaging Research Center (S.G., Y.S.Y., G.S., D.Y.L., M.D.B.) and Department of Radiology (S.G., Y.S.Y., G.S., D.Y.L., K.C.P.L., M.D.B.), Stanford University School of Medicine, 1201 Welch Rd, P260, Stanford, CA 94305-5488. Received July 31, 2002; revision requested September 7; revision received October 11; accepted December 10. Supported in part by the Lucas Foundation, the Phil Allen Trust, and National Institutes of Health grant P41 RR09784. Y.S.Y. and S.G. supported by a research fellowship of the National Cancer Institute at the Lucas Center, Stanford University. Address correspondence to M.D.B. (e-mail: mark@s-word.stanford.edu).

To gain a better understanding of gene expression patterns in tumors, the authors used contrast material–enhanced magnetic resonance (MR) imaging to noninvasively characterize regions within the same tumor to provide a correlate for genomic analysis. Gene expression profiles of samples from a mouse tumor model obtained from contrast-enhanced and nonenhanced regions within the same tumor were compared with MR imaging and functional genomics. From these samples, 11,000 genes were analyzed: 10 genes were up-regulated in the contrast-enhanced areas, and one gene was up-regulated in the nonenhanced regions. Several of these genes encode extracellular matrix proteins. Findings in this study demonstrate that MR imaging can serve as a powerful noninvasive tool for characterizing different regions of tumors to guide genomic analysis with high spatial and temporal resolution.

© RSNA, 2003

Index terms: Genes and genetics • Magnetic resonance (MR), experimental studies, **.12143




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