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Dual-Energy Contrast-enhanced Digital Subtraction Mammography: Feasibility¹

¹ From the Department of Radiology, University of Colorado Health Sciences Center, Denver; and Department of Radiology, University of Colorado Hospital Breast Center, Rm 3140A/Mailstop F724, 1635 N Ursula St, Aurora, CO 80010. From the 2001 RSNA scientific assembly. Received October 3, 2002; revision requested November 27; final revision received March 17, 2003; accepted April 7. Supported by a grant from the Susan G. Komen Breast Cancer Foundation. Address correspondence to J.M.L. (e-mail: john.lewin@uchsc.edu).

A technique for demonstrating breast cancers, dual-energy contrast agent–enhanced digital subtraction mammography, was performed in 26 subjects with mammographic or clinical findings that warranted biopsy. The technique consists of high-energy and low-energy digital mammography after administration of iodinated contrast agent. Weighted subtraction of the logarithmic transform of these images is then performed to obtain an image that preferentially shows iodine. Of the 26 subjects, 13 had invasive cancers. Eleven of these tumors enhanced strongly, one enhanced moderately, and one enhanced weakly. The duct in one patient with ductal carcinoma in situ was weakly enhancing. In the other 12 patients, benign tissue enhanced diffusely in two and weakly focally in two. These results indicate that the technique is feasible and worthy of further study.

© RSNA, 2003

Index terms: Breast radiography, comparative studies, 00.119 • Breast radiography, technology, 00.119

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