HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2292021128v1 229/2/409    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Annet, L. Articles by Van Beers, B. E. Search for Related Content PubMed PubMed Citation Articles by Annet, L. Articles by Van Beers, B. E.

Hepatic Flow Parameters Measured with MR Imaging and Doppler US: Correlations with Degree of Cirrhosis and Portal Hypertension¹

¹ From the Department of Radiology (L.A., R.M., E.D., B.E.V.B.) and the Laboratory of Gastroenterology (Y.H.), Université Catholique de Louvain, St-Luc University Hospital, Ave Hippocrate 10, B-1200 Brussels, Belgium; and the Center of Biostatistics and Medical Documentation, Université Catholique de Louvain, Mont-Godinne University Hospital, Yvoir, Belgium (J.J.). Received September 3, 2002; revision requested November 6; final revision received March 13, 2003; accepted April 16. Supported by grant 3.4578.00 from Fonds National de la Recherche Scientifique, Belgium. L.A. is a research fellow of the Fonds National de la Recherche Scientifique. Address correspondence to L.A. (e-mail: laurence.annet@clin.ucl.ac.be).

PURPOSE: To determine the correlations between hemodynamic parameters of hepatic flow measured with magnetic resonance (MR) imaging and Doppler ultrasonography (US) and the severity of cirrhosis and portal hypertension.

MATERIALS AND METHODS: Forty-six patients referred for measurements of portal venous pressure (three with normal liver, 12 with chronic hepatitis, and 31 with cirrhosis [10 with Child-Pugh class A cirrhosis; 13 with class B cirrhosis; and eight with class C cirrhosis]) were included in the study. Apparent liver perfusion, apparent arterial and portal perfusion, portal fraction, distribution volume, and mean transit time were measured with dynamic contrast material–enhanced MR imaging. Portal velocity, portal flow, congestion index, right hepatic artery resistance index, and modified hepatic index were measured with Doppler US. Results in patients with cirrhosis and those without cirrhosis were compared with the Wilcoxon rank sum test. Correlations were assessed with Spearman rank correlation coefficients.

RESULTS: With MR imaging, all flow parameters except distribution volume were significantly different between patients with and those without cirrhosis (P < .05). There was a significant correlation between all flow parameters measured with MR imaging and portal pressure (P < .02). Apparent arterial (P = .024) and portal (P < .001) perfusion, portal fraction (P < .001), and mean transit time (P = .004) were correlated with Child-Pugh class. Flow parameters measured with Doppler US did not differ significantly between patients with and those without cirrhosis. Only right hepatic arterial resistance (P < .007) and portal flow (P < .043) were weakly (r < 0.7) correlated with portal pressure. No Doppler US parameter was correlated with Child-Pugh class.

CONCLUSION: Hepatic flow parameters measured with MR imaging correlate with the severity of cirrhosis and portal hypertension. Doppler US parameters are only weakly correlated with portal pressure.

© RSNA, 2003

Index terms: Liver, blood supply, 761.12144 • Liver, cirrhosis, 761.288 • Liver, MR, 761.121412, 761.12143, 761.12144 • Liver, US, 761.12984 • Magnetic resonance (MR), perfusion study, 761.12144

This article has been cited by other articles:

				T. S. Koh, C. H. Thng, P. S. Lee, S. Hartono, H. Rumpel, B. C. Goh, and S. Bisdas Hepatic Metastases: In Vivo Assessment of Perfusion Parameters at Dynamic Contrast-enhanced MR Imaging with Dual-Input Two-Compartment Tracer Kinetics Model Radiology, August 11, 2008; (2008) 2483071958. [Abstract] [Full Text]

				H. Kim, C. J. Booth, A. B. Pinus, P. Chen, A. Lee, M. Qiu, M. Whitlock, P. S. Murphy, and R. T. Constable Induced Hepatic Fibrosis in Rats: Hepatic Steatosis, Macromolecule Content, Perfusion Parameters, and Their Correlations--Preliminary MR Imaging in Rats Radiology, June 1, 2008; 247(3): 696 - 705. [Abstract] [Full Text] [PDF]

				M. A. Bali, T. Metens, V. Denolin, V. De Maertelaer, J. Deviere, and C. Matos Pancreatic Perfusion: Noninvasive Quantitative Assessment with Dynamic Contrast-enhanced MR Imaging without and with Secretin Stimulation in Healthy Volunteers--Initial Results Radiology, April 1, 2008; 247(1): 115 - 121. [Abstract] [Full Text] [PDF]

				M. Hagiwara, H. Rusinek, V. S. Lee, M. Losada, M. A. Bannan, G. A. Krinsky, and B. Taouli Advanced Liver Fibrosis: Diagnosis with 3D Whole-Liver Perfusion MR Imaging--Initial Experience Radiology, March 1, 2008; 246(3): 926 - 934. [Abstract] [Full Text] [PDF]

				L. Zhang, Y.-Y. Duan, J.-M. Li, and J.-K. Yin Hemodynamic Features of Doppler Ultrasonography in Patients With Portal Hypertension: Intraoperative Direct Measurement of Portal Pressure in the Portal Venous System J. Ultrasound Med., December 1, 2007; 26(12): 1689 - 1696. [Abstract] [Full Text] [PDF]

				L. Huwart, C. Sempoux, N. Salameh, J. Jamart, L. Annet, R. Sinkus, F. Peeters, L. C. ter Beek, Y. Horsmans, and B. E. Van Beers Liver Fibrosis: Noninvasive Assessment with MR Elastography versus Aspartate Aminotransferase to-Platelet Ratio Index Radiology, November 1, 2007; 245(2): 458 - 466. [Abstract] [Full Text] [PDF]

				B. Taouli, A. J. Tolia, M. Losada, J. S. Babb, E. S. Chan, M. A. Bannan, and H. Tobias Diffusion-Weighted MRI for Quantification of Liver Fibrosis: Preliminary Experience Am. J. Roentgenol., October 1, 2007; 189(4): 799 - 806. [Abstract] [Full Text] [PDF]

				D. A. Aguirre, C. A. Behling, E. Alpert, T. I. Hassanein, and C. B. Sirlin Liver Fibrosis: Noninvasive Diagnosis with Double Contrast Material-enhanced MR Imaging. Radiology, May 1, 2006; 239(2): 425 - 437. [Abstract] [Full Text] [PDF]

				M Pinzani Non-invasive evaluation of hepatic fibrosis: don't count your chickens before they're hatched Gut, March 1, 2006; 55(3): 310 - 312. [Full Text] [PDF]

				A. Haktanir, B. S. Cihan, C. Celenk, and S. Cihan Value of Doppler Sonography in Assessing the Progression of Chronic Viral Hepatitis and in the Diagnosis and Grading of Cirrhosis J. Ultrasound Med., March 1, 2005; 24(3): 311 - 321. [Abstract] [Full Text] [PDF]

				P. V. Pandharipande, G. A. Krinsky, H. Rusinek, and V. S. Lee Perfusion Imaging of the Liver: Current Challenges and Future Goals Radiology, March 1, 2005; 234(3): 661 - 673. [Abstract] [Full Text] [PDF]