Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print October 2, 2003, 10.1148/radiol.2292021156
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2292021156v1
229/2/587    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prescot, A. P.
Right arrow Articles by Dzik-Jurasz, A. S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prescot, A. P.
Right arrow Articles by Dzik-Jurasz, A. S. K.
(Radiology 2003;229:587-592.)
© RSNA, 2003

Technical Developments

Human Gallbladder Bile: Noninvasive Investigation in Vivo with Single-Voxel 1H MR Spectroscopy1

Andrew P. Prescot, MChem, David J. Collins, BA, Martin O. Leach, PhD and Andrzej S. K. Dzik-Jurasz, PhD, FRCS, FRCR

1 From the Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Surrey, England (A.P.P., M.O.L., A.S.K.D.J.); and Royal Marsden National Health Service Trust, Sutton, England (D.J.C.). Received September 9, 2002; revision requested November 18; revision received January 6, 2003; accepted February 25. Supported by Cancer Research UK grant SP1780/0103 and Medical Research Council grant GU 78/6400. Address correspondence to A.S.K.D.J., GlaxoSmithKline Pharmaceuticals, Building 5, Floor 1, Room 13, 890–995 Greenford Rd, London UB6 0HE, England (e-mail: andrzej.s.dzik-jurasz@gsk.com).

Proton (hydrogen 1) magnetic resonance (MR) spectroscopy was used to study model and porcine bile in vitro. The method was subsequently developed to facilitate the acquisition of in vivo 1H MR spectra from the gallbladder bile of 10 human volunteers. Signals attributable to phosphotidylcholine and conjugated bile acid protons were observed in eight of the 10 volunteers. Phosphotidylcholine concentrations were estimated, and five values (mean = 35.8 mmol/L, SD = 9.8) were within the expected range of levels in human bile. Findings in this preliminary investigation indicate that human gallbladder bile can be qualitatively and quantitatively studied noninvasively with 1H MR spectroscopy.

© RSNA, 2003

Index terms: Bile ducts, MR, 768.12145 • Gallbladder, MR, 762.12145




This article has been cited by other articles:


Home page
 Br. J. Radiol.Home page
A Dzik-Jurasz
The development and application of functional nuclear magnetic resonance to in vivo therapeutic anticancer research: 2002 Sir Godfrey Hounsfield lecture delivered at the President's Day, Manchester
Br. J. Radiol., April 1, 2004; 77(916): 296 - 307.
[Abstract] [Full Text] [PDF]