| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neuroradiology |
1 From the Departments of Biomedical Engineering (G.Z., W.L.), Radiology (W.L., K.P.W.), Neurology (W.L.), Psychiatry (G.G., J.H.G.), and Computer Sciences (G.G.), University of North Carolina at Chapel Hill, CB #7515, Chapel Hill, NC 27599. Received November 14, 2002; revision requested January 15, 2003; final revision received April 24; accepted May 20. Supported in part by center grants HD 03110 and MH 33127 and R01 grant NS 37312. Address correspondence to W.L. (e-mail: linw@email.unc.edu).
PURPOSE: To evaluate the normal brains of adults and neonates for regional and age-related differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA).
MATERIALS AND METHODS: Eight healthy adults and 20 healthy neonates were examined with a 3.0-T head-only magnetic resonance (MR) imaging unit by using a single-shot diffusion-tensor sequence. Trace ADC maps, FA maps, directional maps of the putative directions of white matter (WM) tracts, and fiber-tracking maps were obtained. Regions of interest—eight in WM and one in gray matter (GM)—were predefined for the ADC and FA measurements. The Student t test was used to compare FA and ADC between adults and neonates, whereas the Tukey multiple-comparison test was used to compare FA and ADC in different brain regions in the adult and neonate groups.
RESULTS: A global elevation in ADC (P < .001) in both GM and WM and a reduction in FA (P < .001) in WM were observed in neonates as compared with these values in adults. In addition, significant regional variations in FA and ADC were observed in both groups. Regional variations in FA and ADC were less remarkable in adults, whereas neonates had consistently higher FA values and lower ADC values in the central WM as compared with these values in the peripheral WM. Fiber tracking revealed only major WM tracts in the neonates but fibers extending to the peripheral WM in the adults.
CONCLUSION: There were regional differences in FA and ADC values in the neonates; such variations were less remarkable in the adults.
© RSNA, 2003
Index terms: Brain, diffusion • Brain, growth and development • Brain, MR, 13.121412, 13.121413, 13.121416, 13.121417, 13.12144 • Magnetic resonance (MR), diffusion study, 13.12144
This article has been cited by other articles:
|
|
 |
|
  A. M. McKinney, S. A. Kieffer, R. T. Paylor, K. S. SantaCruz, A. Kendi, and L. Lucato Acute Toxic Leukoencephalopathy: Potential for Reversibility Clinically and on MRI With Diffusion-Weighted and FLAIR Imaging Am. J. Roentgenol., July 1, 2009; 193(1): 192 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.L. Escolar, M.D. Poe, J.K. Smith, J.H. Gilmore, J. Kurtzberg, W. Lin, and M. Styner Diffusion Tensor Imaging Detects Abnormalities in the Corticospinal Tracts of Neonates with Infantile Krabbe Disease AJNR Am. J. Neuroradiol., May 1, 2009; 30(5): 1017 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Gao, W. Lin, Y. Chen, G. Gerig, J.K. Smith, V. Jewells, and J.H. Gilmore Temporal and Spatial Development of Axonal Maturation and Myelination of White Matter in the Developing Brain AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 290 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Murakami, M. Morimoto, K. Yamada, O. Kizu, A. Nishimura, T. Nishimura, and T. Sugimoto Fiber-Tracking Techniques Can Predict the Degree of Neurologic Impairment for Periventricular Leukomalacia Pediatrics, September 1, 2008; 122(3): 500 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.H. Gilmore, W. Lin, I. Corouge, Y.S.K. Vetsa, J.K. Smith, C. Kang, H. Gu, R.M. Hamer, J.A. Lieberman, and G. Gerig Early Postnatal Development of Corpus Callosum and Corticospinal White Matter Assessed with Quantitative Tractography AJNR Am. J. Neuroradiol., October 1, 2007; 28(9): 1789 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Upadhyay, M. Ducros, T. A. Knaus, K. A. Lindgren, A. Silver, H. Tager-Flusberg, and D.-S. Kim Function and Connectivity in Human Primary Auditory Cortex: A Combined fMRI and DTI Study at 3 Tesla Cereb Cortex, October 1, 2007; 17(10): 2420 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Provenzale, L. Liang, D. DeLong, and L. E. White Diffusion Tensor Imaging Assessment of Brain White Matter Maturation During the First Postnatal Year Am. J. Roentgenol., August 1, 2007; 189(2): 476 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oouchi, K. Yamada, K. Sakai, O. Kizu, T. Kubota, H. Ito, and T. Nishimura Diffusion Anisotropy Measurement of Brain White Matter Is Affected by Voxel Size: Underestimation Occurs in Areas with Crossing Fibers AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1102 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. van Pul, J. Buijs, A. Vilanova, F. G. Roos, and P. F. F. Wijn Infants with Perinatal Hypoxic Ischemia: Feasibility of Fiber Tracking at Birth and 3 Months Radiology, July 1, 2006; 240(1): 203 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Okada, Y. Miki, Y. Fushimi, T. Hanakawa, M. Kanagaki, A. Yamamoto, S.-i. Urayama, H. Fukuyama, M. Hiraoka, and K. Togashi Diffusion-Tensor Fiber Tractography: Intraindividual Comparison of 3.0-T and 1.5-T MR Imaging Radiology, February 1, 2006; 238(2): 668 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Fabiano, M. A. Horsfield, and R. Bakshi Interhemispheric Asymmetry of Brain Diffusivity in Normal Individuals: A Diffusion-Weighted MR Imaging Study AJNR Am. J. Neuroradiol., May 1, 2005; 26(5): 1089 - 1094. [Abstract] [Full Text] [PDF]
|
|
