| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cardiac Imaging |
1 From the Department of Radiology (S.M.S., C.J.F., J.P.F.) and Department of Medicine, Division of Cardiology (W.G.C., B.P.S., M.G.), Feinberg School of Medicine, Northwestern University Medical School, Chicago, Ill. Received October 21, 2002; revision requested January 7, 2003; final revision received April 14; accepted April 30. Address correspondence to J.P.F., Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Peter V. Ueberroth Building, Suite 3371, 10945 Le Conte Ave, Los Angeles, CA 90095-7206. (e-mail: pfinn@mednet.ucla.edu).
PURPOSE: To measure cardiopulmonary transit times in patients with heart failure by using low-dose, time-resolved magnetic resonance (MR) angiography and to determine if transit curves reflect conventional MR indexes of cardiac function.
MATERIALS AND METHODS: Twenty-six patients with heart failure and left ventricular (LV) systolic dysfunction (17 men and nine women; age range, 22–78 years) and thirteen control subjects (eight men and five women; age range, 23–59 years) were examined with MR imaging. The examination consisted of rapid cine MR imaging throughout the heart, followed by contrast material–enhanced time-resolved three-dimensional MR angiography of the cardiac chambers and pulmonary vasculature. Time-intensity curves for the pulmonary artery and ascending aorta were derived from the MR angiography images. Cardiopulmonary transit times and dispersions (full widths at half maximum [FWHM]) were determined from the curves. Transit times and FWHM values for the patients with heart failure were compared with control values by using two-tailed t tests, and transit time was correlated with standard LV functional parameters calculated from the cine MR images.
RESULTS: Cardiopulmonary transit times and FWHM values were significantly prolonged in the patients with heart failure compared with those in the control patients (P < .001). Transit time correlated directly with LV end-diastolic and end-systolic volumes and inversely with LV ejection fraction (R > 0.60). However, transit time did not correlate strongly with age, body surface area, heart rate, LV mass, stroke volume, cardiac output, or sphericity index.
CONCLUSION: Time-resolved MR angiography allows determination of cardiopulmonary transit times that are significantly prolonged in heart failure and correlate directly with LV volumes and inversely with LV ejection fraction.
© RSNA, 2003
Index terms: Heart, failure, 51.71 • Heart, flow dynamics • Heart, MR, 51.12142 • Heart, ventricles, 51.71 • Magnetic resonance (MR), vascular studies, 51.12142
This article has been cited by other articles:
|
|
 |
|
  M. Fenchel, R. Saleh, H. Dinh, M. H. Lee, K. Nael, M. Krishnam, S. G. Ruehm, S. Miller, J. Child, and J. P. Finn Juvenile and Adult Congenital Heart Disease: Time-resolved 3D Contrast-enhanced MR Angiography Radiology, August 1, 2007; 244(2): 399 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Jorgensen, M. F. Muller, J. Nel, R. N. Upton, E. Houltz, and S.-E. Ricksten Reduced Intrathoracic Blood Volume and Left and Right Ventricular Dimensions in Patients With Severe Emphysema: An MRI Study Chest, April 1, 2007; 131(4): 1050 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weiss, T. C. Krejcie, and M. J. Avram Transit time dispersion in pulmonary and systemic circulation: effects of cardiac output and solute diffusivity Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H861 - H870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Bruzzi, M. Remy-Jardin, D. Delhaye, A. Teisseire, C. Khalil, and J. Remy When, Why, and How to Examine the Heart During Thoracic CT: Part 1, Basic Principles Am. J. Roentgenol., February 1, 2006; 186(2): 324 - 332. [Abstract] [Full Text] [PDF]
|
|
