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Excised Bone Structures in Mice: Imaging at Three-dimensional Synchrotron Radiation Micro CT¹

¹ From the European Synchrotron Radiation Facility, BP 220, 38043 Grenoble, France (E.M.B., S.N., A.E., F.P.); LBTO, Equipe Mixte, Institut National de la Santé et de la Recherche Médicale, E9901 Faculté de Médecine, Saint-Etienne, France (D.A., L.V.); and CREATIS, UMR 5515 Centre National de la Recherche Scientifique, Villeurbanne, France (S.N., A.E., F.P.). Received May 10, 2002; revision requested July 25; final revision received February 26, 2003; accepted April 30. Supported by a Marie Curie Fellowship of the European Community program Human Potential under contract number HPMF-CT-1999–00194 and by grants from the European Research in Space and Terrestrial Osteoporosis group and Région Rhône-Alpes. Address correspondence to F.P. (peyrin@esrf.fr).

Bone microarchitecture and mineralization were determined at three-dimensional synchrotron radiation micro computed tomography in two inbred mice strains. Distal metaphysis of the left femur was imaged in three dimensions at 6.65 µm, whereas the right femur was analyzed with histomorphometry. Three-dimensional quantitative parameters of trabecular and cortical bone architecture were computed. C3H/HeJ@Ico mice had greater bone density and thicker trabeculae; greater cortical bone density, cortical thickness, and porosity; and greater mineralization than did C57BL/6J@Ico mice. The technique is well suited for assessment of trabecular and cortical bone in small animals and at the same time provides mineralization status in three dimensions.

© RSNA, 2003

Index terms: Animals • Bones, mineralization • Computed tomography (CT), three-dimensional, 40.12117 • Osteoporosis, 40.56 • Synchrotron

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