| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neuroradiology |
1 From the Dept of Radiology, Ohio State Univ Hospitals, 657 Means Hall, 1654 Upham Dr, Columbus, OH 43210-1228 (M.V.K.); Scott and White Clinic and Hospital, Texas A&M Univ Health Science Ctr, Temple (V.M.R.); Dept of Radiology, German Cancer Research Ctr, Heidelberg (M.E.); Dept of Neuroradiology, Univ of Heidelberg, Germany (M.H.); Dept of Neuroradiology, Univ of Kiel, Germany (O.J.); Worldwide Medical Affairs, Bracco Imaging, Milan, Italy (M.A.K.); Medidata, Konstanz, Germany (A.M.); Bracco Altana Pharma, Konstanz, Germany (A.H.S., K.P.L.). Received Aug 30, 2002; revision requested Oct 28; final revision received May 13, 2003; accepted June 9. Address correspondence to M.V.K. (e-mail: knopp-1@medctr.osu.edu).
PURPOSE: To evaluate the safety of and compare the enhancement characteristics of gadobenate dimeglumine (MultiHance; Bracco Imaging, Milan, Italy) with those of a standard gadolinium chelate (gadopentetate dimeglumine, Magnevist; Schering, Berlin, Germany) in primary and secondary brain tumors on the basis of qualitative and quantitative parameters, on an intraindiviual basis.
MATERIALS AND METHODS: Twenty-seven patients with either high-grade glioma or metastases were enrolled in a bicentric intraindividual crossover study to compare lesion enhancement with doses of 0.1 mmol per kilogram of body weight of 0.5 mol/L gadopentetate dimeglumine and 0.5 mol/L gadobenate dimeglumine. MR imaging was performed before injection (T1-weighted spin-echo [SE] and T2-weighted fast SE acquisitions) and at 1, 3, 5, 7, 9, and 16 minutes after injection (T1-weighted SE acquisitions). Qualitative assessment was performed by blinded off-site readers (for 22 patients) and on-site investigators (for 24 patients) in terms of global contrast enhancement, lesion-to-brain contrast, lesion delineation, internal lesion morphology and structure, tumor vascularization, and global image preference. Additional quantitative assessment with region-of-interest analysis was performed by off-site readers alone. Statistical analysis of qualitative data was performed with the Wilcoxon signed rank test, whereas a nonparametric approach was adopted for analysis of quantitative data.
RESULTS: Significant (P < .05) preference for gadobenate dimeglumine over gadopentetate dimeglumine was noted both off-site and on-site for the global assessment of contrast enhancement. For off-site readers 1 and 2 and the on-site investigators, respectively, gadobenate dimeglumine was preferred in 13, 17, and 16 patients; gadopentetate dimeglumine was preferred in four, four, and four patients; and equality was found in five, one, and four patients). Similar preference for gadobenate dimeglumine was noted by off-site readers and on-site investigators for lesion-to-brain contrast and all other qualitative parameters. Off-site quantitative evaluation revealed significantly (P < .05) superior enhancement for gadobenate dimeglumine compared with that for gadopentetate dimeglumine at all time points from 3 minutes after injection.
CONCLUSION: Significantly superior contrast enhancement of intraaxial enhancing brain tumors was achieved with 0.1 mmol/kg gadobenate dimeglumine compared with that with 0.1 mmol/kg gadopentetate dimeglumine.
© RSNA, 2004
Index terms: Brain neoplasms, MR, 10.12143, 10.30 • Gadolinium • Magnetic resonance (MR), contrast media, 10.12143
This article has been cited by other articles:
|
|
 |
|
  F. Pediconi, C. Catalano, S. Padula, A. Roselli, V. Dominelli, S. Cagioli, M. A. Kirchin, G. Pirovano, and R. Passariello Contrast-Enhanced MR Mammography: Improved Lesion Detection and Differentiation with Gadobenate Dimeglumine Am. J. Roentgenol., November 1, 2008; 191(5): 1339 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.A. Rowley, G. Scialfa, P.-y. Gao, J.A. Maldjian, D. Hassell, M.J. Kuhn, F.J. Wippold II, M. Gallucci, B.C. Bowen, I.M. Schmalfuss, et al. Contrast-Enhanced MR Imaging of Brain Lesions: A Large-Scale Intraindividual Crossover Comparison of Gadobenate Dimeglumine versus Gadodiamide AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1684 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Sardanelli, M. Quarenghi, T. Schlosser, and J. Barkhausen Delayed Enhancement of Subendocardial Infarcted Myocardium with Gadobenate Dimeglumine: A Paradoxical Effect--Is a Double Dose Too Much? Radiology, September 1, 2006; 240(3): 914 - 916. [Full Text] [PDF]
|
|
|
|
|
|
K. R. Maravilla, J. A. Maldjian, I. M. Schmalfuss, M. J. Kuhn, B. C. Bowen, F. J. Wippold II, V. M. Runge, M. V. Knopp, S. Kremer, L. J. Wolansky, et al. Contrast Enhancement of Central Nervous System Lesions: Multicenter Intraindividual Crossover Comparative Study of Two MR Contrast Agents Radiology, August 1, 2006; 240(2): 389 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pediconi, C. Catalano, R. Occhiato, F. Venditti, F. Fraioli, A. Napoli, M. A. Kirchin, and R. Passariello Breast Lesion Detection and Characterization at Contrast-enhanced MR Mammography: Gadobenate Dimeglumine versus Gadopentetate Dimeglumine Radiology, October 1, 2005; 237(1): 45 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sardanelli, A. Iozzelli, A. Fausto, A. Carriero, and M. A. Kirchin Gadobenate Dimeglumine-enhanced MR Imaging Breast Vascular Maps: Association between Invasive Cancer and Ipsilateral Increased Vascularity Radiology, June 1, 2005; 235(3): 791 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Doolittle, L. E. Abrey, W. A. Bleyer, S. Brem, T. P. Davis, P. Dore-Duffy, L. R. Drewes, W. A. Hall, J. M. Hoffman, A. Korfel, et al. New Frontiers in Translational Research in Neuro-oncology and the Blood-Brain Barrier: Report of the Tenth Annual Blood-Brain Barrier Disruption Consortium Meeting Clin. Cancer Res., January 15, 2005; 11(2): 421 - 428. [Abstract] [Full Text] [PDF]
|
|
