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DOI: 10.1148/radiol.2302021489
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(Radiology 2004;230:329-337.)
© RSNA, 2004


State of the Art

CT Angiography for Diagnosis of Pulmonary Embolism: State of the Art1

U. Joseph Schoepf, MD and Philip Costello, MD

1 From the Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115. Received November 14, 2002; revision requested January 8, 2003; revision received January 22; accepted March 4. Address correspondence to U.J.S. (e-mail: schoepf@bwh.harvard.edu).

In daily clinical routine, computed tomography (CT) has practically become the first-line modality for imaging of pulmonary circulation in patients suspected of having pulmonary embolism (PE). However, limitations regarding accurate diagnosis of small peripheral emboli have so far prevented unanimous acceptance of CT as the reference standard for imaging of PE. The development of multi–detector row CT has led to improved visualization of peripheral pulmonary arteries and detection of small emboli. The finding of a small isolated clot at pulmonary CT angiography, however, may be increasingly difficult to correlate with results of other imaging modalities, and the clinical importance of such findings is uncertain. Therefore, the most realistic scenario to measure efficacy of pulmonary CT angiography when PE is suspected may be assessment of patient outcome. Meanwhile, the high negative predictive value of a normal pulmonary CT angiographic study and its association with beneficial patient outcome has been demonstrated. While the introduction of multi–detector row technology has improved CT diagnosis of PE, it has also challenged its users to develop strategies for optimized contrast material delivery, reduction of radiation dose, and management of large-volume data sets created at those examinations.

Supplemental material: radiology.rsnajnls.org/cgi/content/full/2302021489/DC1

© RSNA, 2004

Index terms: Computed tomography (CT), angiography • Computed tomography (CT), multi–detector row • Embolism, pulmonary, 60.72, 944.77 • Pulmonary arteries, CT, 944.12911, 944.12912, 944.12915, 944.12916, 944.12918 • State of the Art




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