| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Experimental Studies |
1 From the Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215. From the 2002 RSNA scientific assembly. Received December 30, 2002; revision requested March 10, 2003; final revision received July 10; accepted August 18. Supported by National Cancer Institute grant RO1-CA87992–01A1. Address correspondence to S.N.G. (e-mail: sgoldber@caregroup.harvard.edu).
PURPOSE: To determine the effect of surrounding tissue type on coagulation necrosis from radiofrequency (RF) ablation in a homogeneous animal tumor model.
MATERIALS AND METHODS: Thirty canine venereal sarcomas were implanted in three tissue sites (subcutaneous, kidney, and lung) in 13 mildly immunosuppressed dogs. Five of 25 tumors, which were 19 mm ± 3 (mean ± SD) in diameter, were allocated to each of five groups: (a) subcutaneous tumors, (b) kidney tumors, (c) lung tumors with blood flow, and (d) subcutaneous and (e) renal tumors without blood flow, which was achieved by sacrificing the animal to eliminate tumor perfusion. A sixth group comprised larger subcutaneous tumors (mean diameter, 46 mm ± 4) that were also treated. RF ablation was performed with a 1-cm tip and 5 minutes of ablation at 90°C ± 1. Impedance, temperature, and resultant coagulation diameter were recorded and compared. Data were analyzed statistically, including one-way analysis of variance to determine the effect of tissue conductivity (ie, systemic impedance) on necrosis size and tissue temperatures. Linear regression analysis was used to compare changes in impedance between the control and experimental groups.
RESULTS: Increasing linear correlation was observed between tumor coagulation diameter and overall baseline system impedance (R2 = 0.65). RF ablation of lung tumors resulted in the greatest coagulation diameter (13.0 mm ± 3.5) compared with that in the other groups (P < .01). The smallest coagulation diameter was observed in kidney tumors in the presence of blood flow (7.3 mm ± 0.6) compared with that in the other groups (P < .01). Elimination of blood flow in kidney tumors increased coagulation diameter to 10.3 mm ± 0.6 (P < .01). After RF ablation, coagulation diameter in the subcutaneous tumor groups was the same (mean, 9.8 mm ± 1.0) (difference not significant), regardless of tumor size or presence of blood flow.
CONCLUSION: The characteristics of tissue that surrounds tumor, including vascularity and electric conductivity, affect ablation outcome. Predominance of tissue-specific characteristics will likely result in site-specific differences in RF-induced coagulation necrosis.
© RSNA, 2004
Index terms: Animals • Experimental study, 60.3255, 81.329, 90.9335 • Hyperthermia, 60.3255, 81.329, 90.9335 • Radiofrequency (RF) ablation, 60.3255, 81.329, 90.9335 • Sarcoma, 40.319, 60.3221, 81.329
This article has been cited by other articles:
|
|
 |
|
  J. C. Zhu, T. D. Yan, and D. L. Morris A Systematic Review of Radiofrequency Ablation for Lung Tumors Ann. Surg. Oncol., June 1, 2008; 15(6): 1765 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Durick, P. F. Laeseke, L. S. Broderick, F. T. Lee Jr, L. A. Sampson, T. M. Frey, T. F. Warner, J. P. Fine, D. W. van der Weide, and C. L. Brace Microwave Ablation with Triaxial Antennas Tuned for Lung: Results in an in Vivo Porcine Model Radiology, April 1, 2008; 247(1): 80 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Simon, D. E. Dupuy, T. A. DiPetrillo, H. P. Safran, C. A. Grieco, T. Ng, and W. W. Mayo-Smith Pulmonary Radiofrequency Ablation: Long-term Safety and Efficacy in 153 Patients Radiology, April 1, 2007; 243(1): 268 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Simon, D. E. Dupuy, D. A. Iannitti, D. S. K. Lu, N. C. Yu, B. I. Aswad, R. W. Busuttil, and C. Lassman Intraoperative Triple Antenna Hepatic Microwave Ablation Am. J. Roentgenol., October 1, 2006; 187(4): W333 - W340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. d. Baere, J. Palussiere, A. Auperin, A. Hakime, M. Abdel-Rehim, M. Kind, C. Dromain, A. Ravaud, N. Tebboune, V. Boige, et al. Midterm Local Efficacy and Survival after Radiofrequency Ablation of Lung Tumors with Minimum Follow-up of 1 Year: Prospective Evaluation. Radiology, August 1, 2006; 240(2): 587 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Solazzo, Z. Liu, S. M. Lobo, M. Ahmed, A. U. Hines-Peralta, R. E. Lenkinski, and S. N. Goldberg Radiofrequency Ablation: Importance of Background Tissue Electrical Conductivity--An Agar Phantom and Computer Modeling Study Radiology, August 1, 2005; 236(2): 495 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ahmed, Z. Liu, A. N. Lukyanov, S. Signoretti, C. Horkan, W. L. Monsky, V. P. Torchilin, and S. N. Goldberg Combination Radiofrequency Ablation with Intratumoral Liposomal Doxorubicin: Effect on Drug Accumulation and Coagulation in Multiple Tissues and Tumor Types in Animals Radiology, May 1, 2005; 235(2): 469 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Liu, S. M. Lobo, S. Humphries, C. Horkan, S. A. Solazzo, A. U. Hines-Peralta, R. E. Lenkinski, and S. N. Goldberg Radiofrequency Tumor Ablation: Insight into Improved Efficacy Using Computer Modeling Am. J. Roentgenol., April 1, 2005; 184(4): 1347 - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Horkan, K. Dalal, J. A. Coderre, J. L. Kiger, D. E. Dupuy, S. Signoretti, E. F. Halpern, and S. N. Goldberg Reduced Tumor Growth with Combined Radiofrequency Ablation and Radiation Therapy in a Rat Breast Tumor Model Radiology, April 1, 2005; 235(1): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
