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DOI: 10.1148/radiol.2311021741
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(Radiology 2004;231:272-276.)
© RSNA, 2004

Technical Developments

Measurement of Flow Modification in Phantom Aneurysm Model: Comparison of Coils and a Longitudinally and Axially Asymmetric Stent—Initial Findings1

Stephen Rudin, PhD, Zhou Wang, MS, Iacovos Kyprianou, MS, Kenneth R. Hoffmann, PhD, Ye Wu, MS, Hui Meng, PhD, Lee R. Guterman, PhD, MD, Balazs Nemes, MD, Daniel R. Bednarek, PhD, Jacek Dmochowski, PhD and L. Nelson Hopkins, MD

1 From the Depts of Radiology (S.R., D.R.B., L.N.H.), Neurosurgery (S.R., K.R.H., H.M., L.R.G., B.N., D.R.B., L.N.H.), Physics (S.R., I.K., K.R.H., Y.W., D.R.B.), Physiology and Biophysics (S.R., Z.W., K.R.H., D.R.B.), Mechanical and Aerospace Engineering (H.M.), and Social and Preventative Medicine (J.D.), Toshiba Stroke Research Center, State Univ of New York at Buffalo, 3435 Main St, Buffalo, NY 14214. From the 2002 RSNA scientific assembly. Received Dec 20, 2002; revision requested Feb 28, 2003; final revision received Aug 2; accepted Sep 8. Supported in part by National Institutes of Health grant R01NS38746, a grant from the John R. Oishei Foundation, and an equipment grant from Toshiba. Address correspondence to S.R. (e-mail: srudin@acsu.buffalo.edu).

Dye-dilution imaging sequences were performed and time-density curves were constructed in elastomer vessel aneurysm models to demonstrate the effectiveness of coils and an asymmetric stent in disrupting standard vortex flow. Compared with the use of coils, the use of stents led to marked flow modification, as seen with imaging sequences, and substantially slower inflow, as indicated by time-density curves, owing to the low-porosity region of the stent that covers the aneurysm orifice. These flow examination results indicate that potentially favorable flow modification features can be created by using the described asymmetric stent design, the use of which may lead to alternative methods of image-guided endovascular cerebral aneurysm therapy.

© RSNA, 2004

Index terms: Aneurysm, cerebral, 13.73 • Aneurysm, therapy, 13.1264, 13.1269 • Angiography, 13.125 • Blood, flow dynamics • Experimental study • Phantoms • Stents and prostheses, 13.1269




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