| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Experimental Studies |
1 From the Departments of Radiology (U.H., R.M., C.E., M.F., S.G., S.A., D.K., D.S., T.J.B.) and Cardiac Surgery (J.T.) and Division of Cardiology (D.S.), Massachusetts General Hospital and Harvard Medical School, 100 Charles River Plaza, Suite 400, Boston, MA 02114. Received February 6, 2003; revision requested April 23; final revision received September 26; accepted October 20. Supported in part by the Center for Integration of Medicine and Innovative Technology (CIMIT), Boston, Mass, and the New York Cardiac Center, New York, NY. Address correspondence to U.H. (e-mail: uhoffman@partners.org).
PURPOSE: To assess the role of contrast material–enhanced retrospectively electrocardiographically (ECG) gated multi–detector row computed tomography (CT) in the detection of acute myocardial infarction in a porcine model of total coronary occlusion.
MATERIALS AND METHODS: Seven Yorkshire farm pigs were studied with contrast-enhanced retrospectively ECG-gated multi–detector row CT 3 hours after total occlusion of the distal left anterior descending artery (n = 5) or the second diagonal branch (n = 2). Reformatted short-axis end-systolic and end-diastolic CT data sets were assessed for myocardial perfusion deficits, coronary occlusion, and abnormal myocardial wall motion. Perfusion deficits were compared with microsphere-determined blood flow and triphenyltetrazolium chloride (TTC)–stained tissue samples for infarct assessment by using Bland-Altman analysis and analysis of variance.
RESULTS: Myocardial perfusion deficits, occlusion of the left anterior descending artery or second diagonal branch, and akinesis of the infarcted segment were identified in all five animals that completed the study. One animal died, and one data set had nondiagnostic image quality. The CT end-diastolic (mean, 16.1% ± 4.8 [SD]; range, 8.6%–22.2%) and end-systolic (mean, 17.0% ± 6.4; range, 8.7%–26.8%) volume of perfusion deficit was similar to that of infarcted tissue at TTC staining (mean, 13.6% ± 6.0; range, 7.8%–30.9%). Infarcted myocardium at CT demonstrated a 76.1% reduction in microsphere-determined blood flow and a significant reduction of myocardial CT attenuation compared with normal myocardium (P < .01). Myocardial wall motion analysis demonstrated absence of systolic wall thickening in infarcted myocardium.
CONCLUSION: Multi–detector row CT with retrospective ECG gating permits the detection and further characterization of acute myocardial infarction in a porcine model of complete coronary occlusion.
© RSNA, 2004
Index terms: Animals • Computed tomography (CT), angiography, 51.12113, 51.12116 • Computed tomography (CT), experimental studies • Myocardium, infarction, 511.771
This article has been cited by other articles:
|
|
 |
|
  H.-J. Chang, R. T. George, K. H. Schuleri, K. Evers, K. Kitagawa, J. A.C. Lima, and A. C. Lardo Prospective Electrocardiogram-Gated Delayed Enhanced Multidetector Computed Tomography Accurately Quantifies Infarct Size and Reduces Radiation Exposure J. Am. Coll. Cardiol. Img., April 1, 2009; 2(4): 412 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Holz, R. Lautamaki, T. Sasano, J. Merrill, S. G. Nekolla, A. C. Lardo, and F. M. Bengel Expanding the Versatility of Cardiac PET/CT: Feasibility of Delayed Contrast Enhancement CT for Infarct Detection in a Porcine Model J. Nucl. Med., February 1, 2009; 50(2): 259 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Cury, K. Nieman, M. D. Shapiro, J. Butler, C. H. Nomura, M. Ferencik, U. Hoffmann, S. Abbara, D. S. Jassal, T. Yasuda, et al. Comprehensive Assessment of Myocardial Perfusion Defects, Regional Wall Motion, and Left Ventricular Function by Using 64-Section Multidetector CT Radiology, August 1, 2008; 248(2): 466 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sato, M. Hiroe, T. Nozato, H. Hikita, Y. Ito, H. Ohigashi, M. Tamura, A. Takahashi, M. Isobe, and K. Aonuma Early validation study of 64-slice multidetector computed tomography for the assessment of myocardial viability and the prediction of left ventricular remodelling after acute myocardial infarction Eur. Heart J., February 2, 2008; 29(4): 490 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Tops, S. C. Krishnan, J. D. Schuijf, M. J. Schalij, and J. J. Bax Noncoronary applications of cardiac multidetector row computed tomography. J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 94 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. White and D. Kuo Chest Pain in the Emergency Department: Role of Multidetector CT Radiology, December 1, 2007; 245(3): 672 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J H Arnett, K Mohajer, and S A Okon Evidence of acute myocardial infarction on CT Br. J. Radiol., September 1, 2007; 80(957): e219 - e221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Baks, F. Cademartiri, A. D. Moelker, W. J. van der Giessen, G. P. Krestin, D. J. Duncker, and P. J. de Feyter Assessment of Acute Reperfused Myocardial Infarction with Delayed Enhancement 64-MDCT Am. J. Roentgenol., February 1, 2007; 188(2): W135 - W137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. George, C. Silva, M. A.S. Cordeiro, A. DiPaula, D. R. Thompson, W. F. McCarthy, T. Ichihara, J. A.C. Lima, and A. C. Lardo Multidetector Computed Tomography Myocardial Perfusion Imaging During Adenosine Stress J. Am. Coll. Cardiol., July 4, 2006; 48(1): 153 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Baks, F. Cademartiri, A. D. Moelker, A. C. Weustink, R.-J. van Geuns, N. R. Mollet, G. P. Krestin, D. J. Duncker, and P. J. de Feyter Multislice Computed Tomography and Magnetic Resonance Imaging for the Assessment of Reperfused Acute Myocardial Infarction J. Am. Coll. Cardiol., July 4, 2006; 48(1): 144 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Hoffmann, A. J. Pena, R. C. Cury, S. Abbara, M. Ferencik, F. Moselewski, U. Siebert, T. J. Brady, and J. T. Nagurney Cardiac CT in Emergency Department Patients with Acute Chest Pain. RadioGraphics, July 1, 2006; 26(4): 963 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Gerber, B. Belge, G. J. Legros, P. Lim, A. Poncelet, A. Pasquet, G. Gisellu, E. Coche, and J.-L. J. Vanoverschelde Characterization of Acute and Chronic Myocardial Infarcts by Multidetector Computed Tomography: Comparison With Contrast-Enhanced Magnetic Resonance Circulation, February 14, 2006; 113(6): 823 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Lardo, M. A.S. Cordeiro, C. Silva, L. C. Amado, R. T. George, A. P. Saliaris, K. H. Schuleri, V. R. Fernandes, M. Zviman, S. Nazarian, et al. Contrast-Enhanced Multidetector Computed Tomography Viability Imaging After Myocardial Infarction: Characterization of Myocyte Death, Microvascular Obstruction, and Chronic Scar Circulation, January 24, 2006; 113(3): 394 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Mahnken, R. Koos, M. Katoh, J. E. Wildberger, E. Spuentrup, A. Buecker, R. W. Gunther, and H. P. Kuhl Assessment of Myocardial Viability in Reperfused Acute Myocardial Infarction Using 16-Slice Computed Tomography in Comparison to Magnetic Resonance Imaging J. Am. Coll. Cardiol., June 21, 2005; 45(12): 2042 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lembcke, P. M. Dohmen, M. Dewey, C. Klessen, T. Elgeti, K.-G. A. Hermann, W. F. Konertz, B. Hamm, and D. E. Kivelitz Multislice Computed Tomography for Preoperative Evaluation of Right Ventricular Volumes and Function: Comparison With Magnetic Resonance Imaging Ann. Thorac. Surg., April 1, 2005; 79(4): 1344 - 1351. [Abstract] [Full Text] [PDF]
|
|
