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Published online before print June 23, 2004, 10.1148/radiol.2322030198
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(Radiology 2004;232:461-465.)
© RSNA, 2004

Neuroradiology

Increased Brain Apparent Diffusion Coefficient in Tuberous Sclerosis1

Francesco G. Garaci, MD, Roberto Floris, MD, Alessandro Bozzao, MD, Guglielmo Manenti, MD, Alessandra Simonetti, MD, Tommaso Lupattelli, MD, Paolo Curatolo, MD and Giovanni Simonetti, MD

1 From the Departments of Diagnostic Imaging and Interventional Radiology (F.G.G., R.F., G.M., G.S.), Pediatrics (A.S.), and Neuroscience (P.C.), University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy; Department of Neuroradiology, University of Rome La Sapienza, Italy (A.B.); and Department of Radiology, University of Perugia, Italy (T.L.). Received February 5, 2003; revision requested April 14; final revision received October 27; accepted January 5, 2004. Address correspondence to F.G.G. (e-mail: francescogaraci@tiscali.it).

PURPOSE: To evaluate the water diffusivity of normal-appearing white matter (NAWM) in patients with tuberous sclerosis complex compared with that in control subjects.

MATERIALS AND METHODS: Diffusion and conventional magnetic resonance (MR) imaging examinations were performed in 18 patients with clinically established tuberous sclerosis complex (10 male and eight female patients; mean age, 20.1 years; range, 12–30 years), as well as in 18 age-matched control subjects (nine male and nine female; mean age, 20.2 years; range, 11–28 years). Apparent diffusion coefficients (ADCs) were generated, and small elliptic regions of interest were manually placed both in perilesional NAWM and in six anatomic locations of NAWM remote from hamartomatous lesions. Perilesional ADCs were compared with those at the same anatomic site on the contralateral side of the brain (generalized linear regression analysis). ADCs from the predetermined sites in patients were compared with those in control subjects (generalized linear regression analysis).

RESULTS: Supratentorial ADCs were higher in patients with tuberous sclerosis complex than in control subjects, and statistically significant differences were observed in the occipital white matter, frontal white matter, centrum semiovale, parietal white matter, and corona radiata (for each location, P < .001). Significant increases were also seen in the perilesional NAWM compared with NAWM at the same anatomic locations on the contralateral side (P < .001). Infratentorial ADCs were normal.

CONCLUSION: Significant ADC increases were measured in the supratentorial NAWM.

© RSNA, 2004

Index terms: Brain, MR, 13.12144 • Brain, white matter • Magnetic resonance (MR), diffusion study • Sclerosis, tuberous, 13.1832




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