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DOI: 10.1148/radiol.2322030729
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(Radiology 2004;232:499-507.)
© RSNA, 2004

Vascular and Interventional Radiology

Percutaneous Intentional Extraluminal Recanalization in Patients with Chronic Critical Limb Ischemia1

David J. Spinosa, MD, Daniel A. Leung, MD, Alan H. Matsumoto, MD, Eric A. Bissonette, MS, Dorothy Cage, RN, MSN, ACNP, Nancy L. Harthun, MD, John A. Kern, MD, John F. Angle, MD, Klaus D. Hagspiel, MD, Ivan K. Crosby, MD, Harry A. Wellons, Jr, MD, Curtis G. Tribble, MD and Gary D. Hartwell, DSc

1 From the Departments of Radiology (D.J.S., D.A.L., A.H.M., D.C., J.F.A., K.D.H., G.D.H.), Surgery (N.L.H., J.A.K., I.K.C., H.A.W., C.G.T.), and Health Evaluation Sciences (E.A.B.), University of Virginia Health Science Center, PO Box 170, Charlottesville, VA 22909. Received May 2, 2003; revision requested July 11; final revision received December 5; accepted January 5, 2004. Address correspondence to D.J.S. (e-mail: djs4m@hscmail.mcc.virginia.edu).

PURPOSE: To review percutaneous intentional extraluminal recanalization (PIER) for treatment of patients who are poor candidates for infrainguinal arterial bypass surgery (IABS) and have arterial occlusions and chronic critical limb ischemia (CCLI).

MATERIALS AND METHODS: Patients with CCLI who were poor candidates for IABS were candidates for PIER. PIER was performed to create continuous arterial flow to the foot for limb salvage. PIER was attempted in 40 patients (22 men, 18 women; median age, 69 years; age range, 44–87 years). Of these patients, 24 (60%) had diabetes, 17 (42%) had renal disease, and 26 (66%) had coronary artery disease. Wound healing was evaluated at follow-up. Kaplan-Meier curves were constructed to evaluate limb salvage, survival, and amputation-free survival.

RESULTS: Fifty procedures were attempted in 44 limbs. Tissue loss was present in 40 (91%) limbs, and rest pain was present in four (9%); technical success occurred in 38 (86%). Thirty-seven (84%) of 44 limbs treated with PIER involved tibial vessels (tibial vessels only, n = 15; tibial and superior femoral artery [SFA] and/or popliteal vessels, n = 22). Sixty-six infrainguinal arterial vessel segments (SFA, n = 29; tibial, n = 37) in 38 limbs (1.7 segments per limb) were successfully treated with PIER. Thirty-five (95%) of 37 tibial occlusions and 24 (83%) of 29 SFA and/or popliteal occlusions were longer than 10 cm. Median run-off scores were 5.3 (range, 3–8) and 6.6 (range, 3–9) for patients with tibial occlusions and SFA and/or popliteal occlusions, respectively, as scored with modified Rutherford weighting of run-off arteries. Median follow-up was 7.8 months (range, 1–24 months). Twelve months after PIER, Kaplan-Meier analysis showed limb salvage rate was 66%, survival rate was 71%, and amputation-free survival rate was 48% in these patients. The 30-day mortality rate was 2.5%. Major complications occurred in four (10%) patients, and minor complications occurred in an additional four (10%).

CONCLUSION: PIER is a useful percutaneous technique for limb salvage in patients with CCLI.

© RSNA, 2004

Index terms: Arteries, extremities, 928.411 • Arteries, grafts and prostheses, 928.1268, 928.1282 • Arteries, interventional procedures, 928.1268, 928.1282




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