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Experimental Studies |
1 From the Advanced Technology Ctr (Y.R., A.O., G.K., Y.M.) and Oncology Inst (T.T.), Chaim Sheba Medical Ctr, Tel-Hashomer 52621, Israel; Dept of Radiology, Universidad Complutense, Madrid, Spain (J.R.C.); Dept of Radiology, Brigham and Women’s Hosp, Harvard Medical School, Boston, Mass (S.E.M.); and Dept of Pharmacology, Faculty of Medicine, Hebrew Univ, Jerusalem, Israel (J.S.C.). Supported by Israel Science Foundation, Israel Cancer Research Fund, Adams Super Ctr for Brain Studies at Tel-Aviv Univ, Izmel program of Israel Ministry of Industry and Commerce, and NIH ROI NS 39335. Received May 18, 2003; revision requested Jul 15; final revision received Nov 18; accepted Jan 13, 2004. Address correspondence to Y.M. (e-mail: yael@tauphy.tau.ac.il).
PURPOSE: To evaluate the use of diffusion-weighted magnetic resonance (MR) imaging with standard and high b values for pretreatment prediction and early detection of tumor response to various antineoplastic therapies in an animal model.
MATERIALS AND METHODS: Mice bearing C26 colon carcinoma tumors were treated with doxorubicin (n = 25) and with aminolevulinic acid–based photodynamic therapy (n = 23). Fourteen mice served as controls. Conventional T2-weighted fast spin-echo and diffusion-weighted MR images were acquired once before therapy and at 6, 24, and 48 hours after treatment. Pretreatment and early (1–2 days) posttreatment water diffusion parameters were calculated and compared with later changes in tumor volumes measured on conventional MR images by using the Pearson correlation test.
RESULTS: In chemotherapy-treated tumors, a significant correlation (P < .002, r = 0.6) was observed between diffusion parameters that reflected tumor viability, measured prior to treatment, and changes in tumor volumes after therapy. This correlation implies that tumors with high pretreatment viability will respond better to chemotherapy than more necrotic tumors. In tumors treated with photodynamic therapy, no such correlation was found. Changes observed in water diffusion 1–2 days after treatment significantly correlated with later tumor growth rate for both therapies (P < .002, r = 0.54 for photodynamic therapy; P < .0003, r = 0.61 for chemotherapy).
CONCLUSION: High-b-value diffusion-weighted MR imaging has potential use for the early detection of response to therapy and for predicting treatment outcome prior to initiation of chemotherapy.
© RSNA, 2004
Index terms: Colon, MR, 75.12141, 75.12144 • Colon neoplasms, 75.321 • Experimental study • Magnetic resonance (MR), diffusion study, 75.12144 • Magnetic resonance (MR), treatment planning, 75.12144
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