HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2332030454v1 233/2/400    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mack, M. G. Articles by Vogl, T. J. Search for Related Content PubMed PubMed Citation Articles by Mack, M. G. Articles by Vogl, T. J.

Breast Cancer Metastases in Liver: Laser-induced Interstitial Thermotherapy—Local Tumor Control Rate and Survival Data¹

¹ From the Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Received March 24, 2003; revision requested June 18; final revision received February 20, 2004; accepted March 23. Address correspondence to M.G.M. (e-mail: M.Mack@em.uni-frankfurt.de).

PURPOSE: To evaluate the local tumor control rate and survival data for magnetic resonance (MR) imaging–guided laser ablation of breast cancer liver metastases by using laser-induced interstitial thermotherapy (LITT).

MATERIALS AND METHODS: MR-guided LITT was performed in 232 female patients with 578 liver metastases from breast cancer. Survival rates were calculated with the Kaplan-Meier method. Indications for the procedure were defined for patients with no more than five metastases, none of which were larger than 5 cm in diameter, as follows: recurrent liver metastases after partial liver resection (8.2%), metastases in both liver lobes (45.2%), locally nonresectable tumors (19%), general contraindications for surgery (2.6%), or refusal to undergo surgical resection (25%).

RESULTS: Local recurrence rate at 6-month follow-up after LITT was 2.3% (five of 213) for metastases up to 2 cm in diameter, 4.3% (seven of 162) for metastases 2–3 cm in diameter, 3.2% (two of 63) for metastases 3–4 cm in diameter, and 1.9% (one of 52) for metastases larger than 4 cm in diameter. No additional local tumor progression was observed beyond 6 months. The mean survival rate for all treated patients, with calculation started on the date of diagnosis of the metastases treated with LITT, was 4.9 years (95% confidence interval: 4.3, 5.4). The median survival was 4.3 years; 1-year survival, 96%; 2-year survival, 80%; 3-year survival, 63%; and 5-year survival, 41%. The mean survival after the first LITT treatment was 4.2 years (95% confidence interval: 3.6, 4.8).

CONCLUSION: MR-guided LITT yields high local tumor control and survival rates in patients with liver metastases from breast cancer.

© RSNA, 2004

Index terms: Breast neoplasms, metastases, 00.30, 761.33 • Lasers, interstitial therapy • Liver neoplasms, metastases, 76.33 • Liver neoplasms, MR, 76.121411, 76.121412, 76.12143 • Magnetic resonance (MR), guidance, 76.121411, 76.121412, 76.12143

This article has been cited by other articles:

				T. J. Vogl, N. N. N. Naguib, K. Eichler, T. Lehnert, H. Ackermann, and M. G. Mack Volumetric Evaluation of Liver Metastases after Thermal Ablation: Long-term Results Following MR-guided Laser-induced Thermotherapy Radiology, December 1, 2008; 249(3): 865 - 871. [Abstract] [Full Text] [PDF]

				K. Altundag, O. Altundag, P. Morandi, M. Gunduz, M. G. Mack, R. Straub, K. Eichler, O. Sollner, T. Lehnert, and T. J. Vogl Hormone Receptor Status in Patients with Breast Cancer and Liver Metastases Treated with Laser-induced Intersititial Thermotherapy * Dr Mack and colleagues respond: Radiology, April 1, 2005; 235(1): 339 - 340. [Full Text] [PDF]