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Spatially Resolved Imaging of Myocardial Function with Strain-encoded MR: Comparison with Delayed Contrast-enhanced MR Imaging after Myocardial Infarction

¹ From the Department of Medicine, Division of Cardiology (J.G., J.A.C.L., B.L.G., K.C.W.), Department of Electrical Engineering (S.S., J.L.P., N.F.O.), and Department of Radiology (D.A.B., N.F.O.), Johns Hopkins University, Baltimore, Md. Received October 15, 2003; revision requested January 8, 2004; revision received January 12; accepted February 2. Supported by NIH/NHLBI grants R29HL-47405, HL-4590, and N01-HC95162. J.G. supported by a Boehringer-Ingelheim grant of the Fédération Française de Cardiologie (Reims, France). Address correspondence to J.G., Henri Mondor University Hospital, Cardiologie 8^ème, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France (e-mail: jgarot@free.fr).

Strain-encoded magnetic resonance (MR) imaging was prospectively evaluated for direct imaging of systolic myocardial strain and compared with cross-registered delayed contrast material–enhanced MR imaging in five healthy volunteers and nine patients with infarction. Local contractile performance was decreased in infarcted myocardium versus that in remote and adjacent myocardium (P < .01) and in adjacent versus remote myocardium (P < .05). The extent of dysfunctional myocardium, as assessed with strain-encoded MR imaging, was greater than that of hyperenhancement, as assessed with delayed contrast-enhanced MR imaging (P < .05). Strain values obtained with strain-encoded MR imaging were strongly correlated with those obtained with three-dimensional tagged MR imaging (r = 0.75, P < .001). Strain-encoded MR imaging provides spatially resolved (1.5 x 2.5-mm) imaging and measurement of myocardial strain in humans without the need for postprocessing, which may improve routine comprehensive evaluation of myocardial viability.

© RSNA, 2004

Index terms: Heart, MR, 511.121412, 511.12143 • Magnetic resonance (MR), comparative studies • Magnetic resonance (MR), contrast enhancement, 511.12143 • Myocardium, infarction, 511.814

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