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Supratentorial Cerebrospinal Fluid Production Rate in Healthy Adults: Quantification with Two-dimensional Cine Phase-Contrast MR Imaging with High Temporal and Spatial Resolution¹

¹ From the Dept of Electrical Engineering, National Taiwan Univ, Taipei, Taiwan, ROC (T.Y.H., H.W.C., M.Y.C., Y.J.L.); Dept of Radiology, Tri-Service General Hosp and National Defense Medical Center, 325, Sec 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, ROC (T.Y.H., H.W.C., L.H.G., S.C.C., C.S.L., C.Y.C.); and Depts of Biomedical Engineering (M.Y.C.) and Radiological Technology (Y.J.L.), Yuan-Pei Univ of Science and Technology, Hsin-Chu, Taiwan, ROC. Received Jun 5, 2003; revision requested Aug 15; revision received Jan 14, 2004; accepted Feb 17. Supported in part by Tri-Service General Hospital with grant TSGH-C90–52 and by National Science Council with grant NSC90–2314-B-002–256. Address correspondence to C.Y.C. (e-mail: sandy0928@seed.net.tw).

A method for objectively determining supratentorial cerebrospinal fluid (CSF) production rate is described. The method employs cine phase-contrast magnetic resonance imaging with high temporal and spatial resolution at the level of the aqueduct of Sylvius. Automatic encircling of the aqueduct was accomplished by using a pulsatility-based segmentation approach. Results in 23 healthy adults (18 men, five women; age range, 21–39 years) yielded an average CSF production rate of 305 µL/min ± 145 (standard deviation); this rate is in good agreement with literature-reported values obtained with invasive ventriculolumbar perfusion measurements. Average operator imprecision was 23.1% if automatic segmentation was not used. The proposed method is potentially an effective means for measuring supratentorial CSF production rate in humans.

© RSNA, 2004

Index terms: Cerebrospinal fluid, flow dynamics, 167.12144 • Cerebrospinal fluid, MR, 167.12144 • Magnetic resonance (MR), phase imaging, 163.12144

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