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Published online before print October 14, 2004, 10.1148/radiol.2333031276
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(Radiology 2004;233:899-904.)
© RSNA, 2004

Technical Developments

Internal Carotid Artery Occlusion Assessed at Pulsed Arterial Spin-labeling Perfusion MR Imaging at Multiple Delay Times1

Jeroen Hendrikse, MD, PhD, Matthias J. P. van Osch, PhD, Dirk R. Rutgers, MD, Chris J. G. Bakker, PhD, L. Jaap Kappelle, MD, PhD, Xavier Golay, PhD and Jeroen van der Grond, PhD

1 From the Depts of Radiology (Hp E 01.132) (J.H., M.J.P.v.O., D.R.R., C.J.G.B., J.v.d.G.) and Neurology (L.J.K.), Univ Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands; Dept of Radiology, Johns Hopkins Univ School of Medicine, Baltimore, Md (X.G.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (X.G.). Received Aug 11, 2003; revision requested Oct 28; final revision received Feb 11, 2004; accepted Mar 8. Address correspondence to J.H. (e-mail: j.hendrikse@azu.nl).

Magnetic resonance (MR) imaging with pulsed arterial spin labeling (ASL) was performed at six different inversion times in nine patients with internal carotid artery (ICA) occlusion and in 11 control subjects. The hospital’s commission on scientific research on human subjects approved the study protocol, and all study subjects gave informed consent. Cerebral blood flow (CBF) in the middle cerebral artery territories was calculated from the combined signal intensities measured with ASL at the multiple inversion times. In the patients with ICA occlusion, mean CBF values were decreased in the gray matter of the hemisphere ipsilateral to the occlusion, as compared with values in the gray matter of the contralateral hemisphere (P < .05) and with values in the gray matter of the control subjects (P < .05). Quantification of CBF with ASL at multiple inversion times can compensate for the blood transit delays in patients with ICA occlusion.

© RSNA, 2004

Index terms: Brain, diffusion, 10.12144 • Carotid arteries, flow dynamics • Carotid arteries, MR, 172.121411, 172.121412, 172.121413, 172.121416, 172.12142, 172.12144, 172.12146 • Carotid arteries, stenosis or obstruction, 172.721 • Magnetic resonance (MR), perfusion study, 10.12144




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