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Published online before print October 29, 2004, 10.1148/radiol.2333032004
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(Radiology 2004;233:921-926.)
© RSNA, 2004


Technical Developments

Myocardial Infarction: Optimization of Inversion Times at Delayed Contrast-enhanced MR Imaging1

Ankur Gupta, MD, Vivian S. Lee, MD, PhD, Yiu-Cho Chung, PhD, James S. Babb, PhD and Orlando P. Simonetti, PhD

1 From the Department of Radiology–MRI, New York University Medical Center, 530 First Ave, New York, NY 10016 (A.G., V.S.L.); and Siemens Medical Solutions, Chicago, Ill (Y.C.C., J.S.B., O.P.S.). Received December 10, 2003; revision requested February 19, 2004; revision received February 23; accepted March 23. Supported by a Seed Grant from the Society of Thoracic Radiology and a New York University General Clinical Research Center Medical Student Grant. Address correspondence to V.S.L. (e-mail: vivian.lee@med.nyu.edu).

Seventeen patients underwent magnetic resonance (MR) imaging for myocardial viability with a protocol approved by the institutional review board and gave written informed consent. Breath-hold cine inversion-recovery segmented k-space true fast imaging with steady-state precession sequence, referred to as inversion time (TI) mapping, was performed to determine optimal TI for myocardial infarction inversion-recovery imaging. From TI mapping, optimal TI was 180–315 msec 10–15 minutes after administration of 0.15 mmol/kg of gadolinium-based contrast material. At that optimal TI, relative signal intensity of infarcted myocardium compared with uninfarcted myocardium was maximal (mean ± standard deviation, 297.8% ± 86.5), whereas signal-to-noise ratio of uninfarcted myocardium was minimal (4.5 ± 1.2). When applied to conventional myocardial infarction inversion-recovery imaging, optimal TI resulted in nulling of signal intensity of uninfarcted myocardium in all patients and in excellent conspicuity of infarcted myocardium in all nine patients with visible infarction.

© RSNA, 2004

Index terms: Magnetic resonance (MR), contrast enhancement • Magnetic resonance (MR), inversion recovery, 51.121413 • Myocardium, infarction, 51.771




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