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Special Report |
1 From the Departments of Radiology and Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157 (J.J.C.); Department of Biostatistics, University of Washington Center for Health Studies, Group Health Cooperative, Seattle, Wash (J.C.N.); Heart Disease Prevention Program, University of California, Irvine, Calif (N.D.W.); Department of Radiology, School of Medicine, University of California, Los Angeles, Calif (M.M.G.); Department of Clinical Medicine, Columbia University, New York, NY (Y.A.); Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn (D.R.J.); Kaiser Permanente Research Division, Oakland, Calif (S.S.); Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md (D.E.B.); Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Ala (O.D.W.); and Harbor-UCLA Research and Education Institute, Los Angeles, Calif (R.C.D.). Received March 5, 2004; revision requested May 13; revision received June 1; accepted June 18. Supported by contracts N01-HC-95159 through N01-HC-95169, as well as N01-HC-48047 through N01-HC-48050 and N01-HC-95095, with the National Heart, Lung, and Blood Institute. Additional support was provided by General Clinical Research Center, Wake Forest University Health Sciences, grant M01-RR07122. Address correspondence to J.J.C.
Calcified coronary artery plaque, measured at cardiac computed tomography (CT), is a predictor of cardiovascular disease and may play an increasing role in cardiovascular disease risk assessment. The Multi-Ethnic Study of Atherosclerosis (MESA) and the Coronary Artery Risk Development in Young Adults (CARDIA) study of the National Heart, Lung, and Blood Institute are population-based studies in which calcified coronary artery plaque was measured with electron-beam and multi–detector row CT and a standardized protocol in 6814 (MESA) and 3044 (CARDIA study) participants. The studies were approved by the appropriate institutional review board from the study site or agency, and written informed consent was obtained from each participant. Participation in the CT examination was high, image quality was good, and agreement for the presence of calcified plaque was high (
= 0.92, MESA; = 0.77, CARDIA study). Extremely high agreement was observed between and within CT image analysts for the presence ( > 0.90, all) and amount (intraclass correlation coefficients, >0.99) of calcified plaque. Measurement of calcified coronary artery plaque with cardiac CT is well accepted by participants and can be implemented with consistently high-quality results with a standardized protocol and trained personnel. If predictive value of calcified coronary artery plaque for cardiovascular events proves sufficient to justify screening a segment of the population, then a standardized cardiac CT protocol is feasible and will provide reproducible results for health care providers and the public.
© RSNA, 2005
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B. I. Freedman, C. D. Langefeld, K. K. Lohman, D. W. Bowden, J. J. Carr, S. S. Rich, and L. E. Wagenknecht Relationship between Albuminuria and Cardiovascular Disease in Type 2 Diabetes J. Am. Soc. Nephrol., July 1, 2005; 16(7): 2156 - 2161. [Abstract] [Full Text] [PDF]
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H. Kramer, D. R. Jacobs Jr, D. Bild, W. Post, M. F. Saad, R. Detrano, R. Tracy, R. Cooper, and K. Liu Urine Albumin Excretion and Subclinical Cardiovascular Disease Hypertension, July 1, 2005; 46(1): 38 - 43. [Abstract] [Full Text] [PDF]
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J. C. Nelson, R. A. Kronmal, J. J. Carr, M. F. McNitt-Gray, N. D. Wong, C. M. Loria, J. G. Goldin, O. D. Williams, and R. Detrano Measuring Coronary Calcium on CT Images Adjusted for Attenuation Differences Radiology, May 1, 2005; 235(2): 403 - 414. [Abstract] [Full Text] [PDF]
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