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Hepatocellular Carcinoma: Role of Unenhanced and Delayed Phase Multi–Detector Row Helical CT in Patients with Cirrhosis¹

¹ From the Departments of Radiological Sciences (R.I., A.L., C.C., P.R., F.M., F.P., R.P.) and Experimental Medicine and Pathology–Medical Biostatistics (I.N.), University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy; and Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan (T.M., M.H.). Received July 29, 2003; revision requested October 10; final revision received April 21, 2004; accepted May 26. Address correspondence to R.I., Via Arturo Graf 40, 00137 Rome, Italy (e-mail: r_iannaccone@yahoo.it).

PURPOSE: To determine, by using multi–detector row helical computed tomography (CT), the added value of obtaining unenhanced and delayed phase scans in addition to biphasic (hepatic arterial and portal venous phases) scans in the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis.

MATERIALS AND METHODS: Local ethical committee approval and patient consent were obtained. One hundred ninety-five patients (129 men, 66 women; mean age, 61 years; age range, 39–78 years) with 250 HCCs underwent multi–detector row helical CT of the liver. A quadruple-phase protocol that included unenhanced, hepatic arterial, portal venous, and delayed phases was performed. Analysis of images from hepatic arterial and portal venous phases combined, hepatic arterial and portal venous phases with the unenhanced phase, hepatic arterial and portal venous phases with the delayed phase, and all phases combined was performed separately by three independent radiologists. Relative sensitivity, positive predictive value, and area under the receiver operating characteristic curve (A_z) were calculated for each reading session.

RESULTS: Mean sensitivity and positive predictive values, respectively, for HCC detection were 88.8% (666 of 750 readings) and 97.8% (666 of 681 readings) for the combined hepatic arterial and portal venous phases, 89.2% (669 of 750 readings) and 97.8% (669 of 684 readings) for hepatic arterial and portal venous phases with the unenhanced phase, 92.8% (696 of 750 readings) and 97.3% (696 of 715 readings) for hepatic arterial and portal venous phases with the delayed phase, and 92.8% (696 of 750 readings) and 97.3% (696 of 715 readings) for all four phases combined. The reading sessions in which delayed phase images were available for interpretation showed significantly (P < .05) superior sensitivity and A_z values.

CONCLUSION: Unenhanced phase images are not effective for HCC detection. Because of the significant increase in HCC detection, a delayed phase can be a useful adjunct to biphasic CT in patients at risk for developing HCC.

© RSNA, 2005

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