| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neuroradiology |
1 From the MR Research Unit, VA Medical Center, 4150 Clement St (114M), San Francisco, CA 94107. Received February 2, 2004; revision requested April 12; revision received May 6; accepted June 15. Supported in part by a research applications grant of the Department of Veterans Affairs REAP. M.W.W. supported by NIH grant AG10897. H.C.C. supported by NIH grant AG12435. Address correspondence to N.S. (e-mail: nschuff@itsa.ucsf.edu).
PURPOSE: To prospectively determine if pulsed arterial spin-labeling perfusion magnetic resonance (MR) imaging depicts regional cerebral hypoperfusion in subjects with Alzheimer disease (AD) and mild cognitive impairment (MCI), compared with perfusion in cognitively normal (CN) subjects, that is consistent with results of fluorodeoxyglucose (FDG) positron emission tomography (PET) and hexamethylpropyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) studies of similar populations.
MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained. Twenty subjects with AD (13 men, seven women; mean age, 72.9 years), 18 with MCI (nine men, nine women; mean age, 73.3 years), and 23 CN subjects (10 men, 13 women; mean age, 72.9 years) underwent arterial spin-labeling and volumetric T1-weighted structural MR imaging. Perfusion images were coregistered to structural images, corrected for partial volume effects (PVEs) with information from the structural image to determine tissue content of perfusion voxels, and normalized to a study-specific template. Analyses of perfusion differences between groups, with and without corrections for PVEs, were performed on a voxel-by-voxel basis with a one-tailed fixed-effects analysis of covariance model adjusted for age. In addition, tests were performed with and without accounting for global perfusion.
RESULTS: The AD group showed significant regional hypoperfusion, compared with the CN group, in the right inferior parietal cortex extending into the bilateral posterior cingulate gyri (P < .001), bilateral superior and middle frontal gyri (P < .001), and left inferior parietal lobe (P = .007). When PVEs from underlying cortical gray matter atrophy were accounted for, the AD group still showed hypoperfusion in the right inferior parietal lobe extending into the bilateral posterior cingulate gyri (P < .001) and left (P = .003) and right (P = .012) middle frontal gyri. With a more liberal voxel-level threshold of P < .01, the MCI group showed significant regional hypoperfusion relative to the CN group in the inferior right parietal lobe (P = .046), similar to the region of greatest significance in the AD group.
CONCLUSION: Arterial spin-labeling MR imaging showed regional hypoperfusion with AD, in brain regions similar to those seen in FDG PET and HMPAO SPECT studies of similar populations; this hypoperfusion persists after accounting for underlying cortical gray matter atrophy.
© RSNA, 2005
This article has been cited by other articles:
|
|
 |
|
  A.J. Bastos-Leite, J.P.A. Kuijer, S.A.R.B. Rombouts, E. Sanz-Arigita, E.C. van Straaten, A.A. Gouw, W.M. van der Flier, P. Scheltens, and F. Barkhof Cerebral Blood Flow by Using Pulsed Arterial Spin-Labeling in Elderly Subjects with White Matter Hyperintensities AJNR Am. J. Neuroradiol., August 1, 2008; 29(7): 1296 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Dai, O. L. Lopez, O. T. Carmichael, J. T. Becker, L. H. Kuller, and H. M. Gach Abnormal Regional Cerebral Blood Flow in Cognitively Normal Elderly Subjects With Hypertension Stroke, February 1, 2008; 39(2): 349 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. van Laar, Y. van der Graaf, W. P. T. M. Mali, J. van der Grond, and J. Hendrikse Effect of Cerebrovascular Risk Factors on Regional Cerebral Blood Flow Radiology, December 1, 2007; 246(1): 198 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N SCHUFF and X P ZHU Imaging of mild cognitive impairment and early dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S109 - S114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K HERHOLZ, S F CARTER, and M JONES Positron emission tomography imaging in dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S160 - S167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Xu, P. G. Antuono, J. Jones, Y. Xu, G. Wu, D. Ward, and S. -J. Li Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects Neurology, October 23, 2007; 69(17): 1650 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Johnson, M. L. Ries, T. M. Hess, C. M. Carlsson, C. E. Gleason, A. L. Alexander, H. A. Rowley, S. Asthana, and M. A. Sager Effect of Alzheimer Disease Risk on Brain Function During Self-appraisal in Healthy Middle-aged Adults Arch Gen Psychiatry, October 1, 2007; 64(10): 1163 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Borroni, M. Di Luca, A. Padovani, W .M. van der Flier, N .S.M. Schoonenboom, Y .A.L. Pijnenburg, N .C. Fox, and P . Scheltens The effect of APOE genotype on clinical phenotype in Alzheimer disease Neurology, February 20, 2007; 68(8): 624 - 624. [Full Text] [PDF]
|
|
|
|
|
|
A. T. Du, G. H. Jahng, S. Hayasaka, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. P. Rankin, B. L. Miller, M. W. Weiner, and N. Schuff Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI. Neurology, October 10, 2006; 67(7): 1215 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Johnson, T. W. Schmitz, M. A. Trivedi, M. L. Ries, B. M. Torgerson, C. M. Carlsson, S. Asthana, B. P. Hermann, and M. A. Sager The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation. J. Neurosci., May 31, 2006; 26(22): 6069 - 6076. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
