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Technical Developments |
1 From the Departments of Radiology (J.W., Y.Z., R.L.W., J.A.D.) and Neurology (J.W., A.C.R., J.A.D.) and Center for Functional Neuroimaging (J.W., J.A.D.), University of Pennsylvania, 3 W Gates, 3400 Spruce St, Philadelphia, PA, 19104; and Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass (D.C.A.). Received October 13, 2003; revision requested January 7, 2004; final revision received May 27; accepted June 17. Supported by National Institutes of Health grants HD39621 and DA015149 and National Science Foundation grant BCS0224007. Address correspondence to J.W. (e-mail: wangj3@mail.med.upenn.edu).
Written informed consent was obtained prior to all human studies after the institutional review board approved the protocol. A continuous arterial spin-labeling technique with an amplitude-modulated control was implemented by using a single coil at 3.0 T. Adiabatic inversion efficiency at 3.0 T, comparable to that at 1.5 T, was achieved by reducing the amplitude of radiofrequency pulses and gradient strengths appropriately. The amplitude-modulated control provided a good match for the magnetization transfer effect of labeling pulses, allowing multisection perfusion magnetic resonance imaging of the whole brain. Comparison of multisection continuous and pulsed arterial spin-labeling methods at 3.0 T showed a 33% improvement in signal-to-noise ratio by using the former approach.
© RSNA, 2005
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