HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: 2351040411v1 235/1/65    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by de Lussanet, Q. G. Articles by Backes, W. H. Search for Related Content PubMed PubMed Citation Articles by de Lussanet, Q. G. Articles by Backes, W. H.

Dynamic Contrast-enhanced MR Imaging Kinetic Parameters and Molecular Weight of Dendritic Contrast Agents in Tumor Angiogenesis in Mice¹

¹ From the Department of Radiology (Q.G.d.L., R.G.H.B.T., J.M.A.v.E., W.H.B.) and Angiogenesis Laboratory, Departments of Pathology and Internal Medicine (A.W.G.), Maastricht University Hospital, P. Debyelaan 25, 6202 AZ Maastricht, the Netherlands; and Laboratory of Macromolecular and Organic Chemistry (S.L., M.H.P.v.G.) and Department of Biomedical Engineering (M.H.P.v.G., J.M.A.v.E., W.H.B.), Eindhoven University of Technology, Eindhoven, the Netherlands. Received March 2, 2004; revision requested May 13; revision received June 4; accepted July 8. Supported in part by the Cardiovascular Research Institute, Maastricht, the Netherlands. Address correspondence to Q.G.d.L. (e-mail: qdlu@rdia.azm.nl).

PURPOSE: To evaluate the relationship between dynamic contrast agent–enhanced magnetic resonance (MR) imaging–derived kinetic parameters and contrast agents of equal chemical composition and configuration but with different molecular weights in a tumor angiogenesis model.

MATERIALS AND METHODS: This study was approved by the ethical review committee. Maintenance and care of animals was in compliance with guidelines set by the institutional animal care committee. Dynamic contrast-enhanced MR imaging was performed with dendritic contrast agents in 16 mice with tumor xenografts; mice were placed in groups of four for each molecular weight of the contrast agent. The magnitude and spatial distribution of kinetic parameters (transfer coefficient [K^PS] and plasma fraction [f^PV]) were compared with molecular weight of the contrast agent by determining the Spearman correlation coefficient (r) and the quantitative relationship between the endothelial K^PS and molecular weight.

RESULTS: Inverse relationships between molecular weight of contrast agent and K^PS and f^PV of tumor rim (r = –0.8, P < .001 and r = –0.5, P = .04, respectively) and core (r = –0.7, P = .004 and r = –0.6, P = .01, respectively) were observed. The quantitative relationship between K^PS and molecular weight (MW) was K^PS = 0.4/MW^0.44. A decreasing stepwise pattern in f^PV was noted between contrast agents with low (0.7- and 3.0-kDa) molecular weight and those with high (12- and 51-kDa) molecular weight.

CONCLUSION: Macromolecular permeability is best measured with high-molecular-weight contrast agents; endothelial K^PS values measured with low-molecular-weight contrast agents incorporate tissue perfusion and permeability and demonstrate heterogeneous microcirculatory flow.

© RSNA, 2005

This article has been cited by other articles:

				R. Jain, S.K. Ellika, L. Scarpace, L.R. Schultz, J.P. Rock, J. Gutierrez, S.C. Patel, J. Ewing, and T. Mikkelsen Quantitative Estimation of Permeability Surface-Area Product in Astroglial Brain Tumors Using Perfusion CT and Correlation with Histopathologic Grade AJNR Am. J. Neuroradiol., April 1, 2008; 29(4): 694 - 700. [Abstract] [Full Text] [PDF]

				L. S. Fournier, V. Novikov, V. Lucidi, Y. Fu, T. Miller, E. Floyd, D. M. Shames, and R. C. Brasch MR Monitoring of Cyclooxygenase-2 Inhibition of Angiogenesis in a Human Breast Cancer Model in Rats Radiology, April 1, 2007; 243(1): 105 - 111. [Abstract] [Full Text] [PDF]

				M. Muruganandham, M. Lupu, J. P. Dyke, C. Matei, M. Linn, K. Packman, K. Kolinsky, B. Higgins, and J. A. Koutcher Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5 T. Mol. Cancer Ther., August 1, 2006; 5(8): 1950 - 1957. [Abstract] [Full Text] [PDF]

				A. H. Khandani and R. C. Semelka Can the Relation between Gadopentetate Dimeglumine and FDG Uptake in Colorectal Liver Metastases Be Used Clinically? Radiology, October 1, 2005; 237(1): 1 - 2. [Full Text] [PDF]

				P. L. Choyke Contrast Agents for Imaging Tumor Angiogenesis: Is Bigger Better? Radiology, April 1, 2005; 235(1): 1 - 2. [Full Text] [PDF]